MCC950 (CP-456773) sodium salt is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. MCC950 (CP-456773) sodium salt inhibits interleukin 1β (IL-1β) secretion and caspase 1 processing.
MCC950 also dose dependently inhibit IL-1β but not TNF-α secretion.MCC950 specifically blocks caspase-11-directed NLRP3 activation and IL-1β secretion upon stimulation of the non-canonical pathway. NLRC4-stimulated IL-1β and TNF-α secretion (as activated by Salmonella typhimurium) are not inhibited by MCC950 even at a concentration of 10 µM.
Biomed J. 2023 Feb 7;S2319-4170(23)00004-5.
Inhibition of NLRP3 attenuates sodium dextran sulfate-induced inflammatory bowel disease through gut microbiota regulation
MCC950 sodium salt (CP-456773) purchased from AbMole
Chin J Nat Med. 2023 Sep 6;21(10): 759-774.
Paeonol reduces microbial metabolite α-hydroxyisobutyric acid to alleviate the ROS/TXNIP/NLRP3 pathway-mediated endothelial inflammation in atherosclerosis mice
MCC950 sodium salt (CP-456773) purchased from AbMole
J Neuroimmune Pharmacol. 2022 Dec;17(3-4):503-514.
Inhibition of Microglial NLRP3 with MCC950 Attenuates Microglial Morphology and NLRP3/Caspase-1/IL-1β Signaling In Stress-induced Mice
MCC950 sodium salt (CP-456773) purchased from AbMole
J Inflamm Res. 2022 Sep 13;15:5309-5326.
P2X7R-NEK7-NLRP3 Inflammasome Activation: A Novel Therapeutic Pathway of Qishen Granule in the Treatment of Acute Myocardial Ischemia
MCC950 sodium salt (CP-456773) purchased from AbMole
Front Cell Infect Microbiol. 2022 Aug 9;12:925435.
Outer membrane vesicles of Porphyromonas gingivalis trigger NLRP3 inflammasome and induce neuroinflammation, tau phosphorylation, and memory
MCC950 sodium salt (CP-456773) purchased from AbMole
BMC Neurosci. 2022 Nov 27;23(1):70.
NLRP3 inflammasome regulates astrocyte transformation in brain injury induced by chronic intermittent hypoxia
MCC950 sodium salt (CP-456773) purchased from AbMole
Experimental Lung Research. 2022 Apr-Aug;48(4-6):168-177.
Low tidal volume ventilation alleviates ventilator-induced lung injury by regulating the NLRP3 inflammasome
MCC950 sodium salt (CP-456773) purchased from AbMole
Front Pharmacol. 2021 May 31;12:599393.
Histamine H 3 Receptor Signaling Regulates the NLRP3 Inflammasome Activation in C2C12 Myocyte During Myogenic Differentiation
MCC950 sodium salt (CP-456773) purchased from AbMole
Cell Rep. 2020 May 19;31(7):107667.
hGBP1 Coordinates Chlamydia Restriction and Inflammasome Activation through Sequential GTP Hydrolysis
MCC950 sodium salt (CP-456773) purchased from AbMole
Neurochem Res. 2020 Sep;45(9):2020-2031.
MCC950 Inhibits NLRP3 Inflammasome and Alleviates Axonal Injures in Early Stages of Diffuse Axonal Injury in Rats
MCC950 sodium salt (CP-456773) purchased from AbMole
Journal of Immunology Research. 2018 Sep 30.
Sevoflurane Inhibits the Th2 Response and NLRP3 Expression in Murine Allergic Airway Inflammation.
MCC950 sodium salt (CP-456773) purchased from AbMole
Molecular Weight | 426.46 |
Formula | C20H23N2NaO5S |
CAS Number | 256373-96-3 |
Solubility (25°C) | Water 30 mg/mL DMSO 80 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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