Streptozotocin

Biological Activity

Streptozotocin (STZ) is a kind of glucosamine - nitrosourea derivative.

Solution is extremely unstable at room temperature, and can be decomposed into gas and volatilized after half an hour, freshly prepared is recommended.

Product Citations

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  Acta Biomater. 2023 Sep 13;S1742-7061(23)00544-5.

  Functional insulin aspart/insulin degludec-based microneedles for promoting postprandial glycemic control
  Streptozotocin purchased from AbMole

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  J Cell Physiol. 2023 Jun 3.

  RIG-I contributes to keratinocyte proliferation and wound repair by inducing TIMP-1 expression through NF-κB signaling pathway
  Streptozotocin purchased from AbMole

• 

  Molecules. 2023 Jan 18;28(3):968.

  Anemoside B4 Exerts Hypoglycemic Effect by Regulating the Expression of GLUT4 in HFD/STZ Rats
  Streptozotocin purchased from AbMole

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  PLoS One. 2023 Jul 19;18(7):e0288876.

  Low-dose lipopolysaccharide inducing continuous and obvious increase in urinary protein in hyperglycemic rats and the underlying mechanism
  Streptozotocin purchased from AbMole

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  PLoS One. 2023 Dec 1;18(12):e0294566.

  Silencing of topical proline hydroxylase domain 2 promotes the healing of rat diabetic wounds by phosphorylating AMPK
  Streptozotocin purchased from AbMole

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  Drug Deliv Transl Res. 2022 Feb 6.

  A novel method for fabrication of coated microneedles with homogeneous and controllable drug dosage for transdermal drug delivery
  Streptozotocin purchased from AbMole

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  Drug Deliv Transl Res. 2022 Feb;12(2):459-471.

  Dissolving microneedle rollers for rapid transdermal drug delivery
  Streptozotocin purchased from AbMole

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  Front Pharmacol. 2021 Sep 22;12:719905.

  Dissolving Polymer Microneedles for Transdermal Delivery of Insulin
  Streptozotocin purchased from AbMole

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  Invest Ophthalmol Vis Sci. 2021 Oct 4;62(13):7.

  Neutrophil-Derived Proteases Contribute to the Pathogenesis of Early Diabetic Retinopathy
  Streptozotocin purchased from AbMole

• 

  Drug Deliv Transl Re. 2021 Apr 13.

  Dissolving Microneedle Rollers for Rapid Transdermal Drug Delivery
  Streptozotocin purchased from AbMole

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  Bioengineered. 2021 Dec;12(1):5491-5503.

  The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction
  Streptozotocin purchased from AbMole

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  Sci Adv. 2020 Jul 10;6(28):eaba7260.

  A basal-bolus insulin regimen integrated microneedle patch for intraday postprandial glucose control
  Streptozotocin purchased from AbMole

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  Pharmacol Res. 2020 Jul;157:104831.

  Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy
  Streptozotocin purchased from AbMole

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  2020 Sep.

  Developing a model to assess the contribution of cytokeratin 19-expressing cells during multipotent stromal cell-induced islet regeneration
  Streptozotocin purchased from AbMole

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  Macromol Rapid Commun. 2018 May 2;e1800075.

  Controlled Delivery of Insulin Using Rapidly Separating Microneedles Fabricated from Genipin-Crosslinked Gelatin
  Streptozotocin purchased from AbMole

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  Int J Pharm. 2018 Dec 13;556:338-348.

  Self-implanted tiny needles as alternative to traditional parenteral administrations for controlled transdermal drug delivery.
  Streptozotocin purchased from AbMole

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  J Drug Target. 2018 Jan;16:1-10.

  In-vitro and in-vivo assessment of polymer microneedles for controlled transdermal drug delivery
  Streptozotocin purchased from AbMole

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  J Ind Eng Chem. 2017;3311:1–7.

  Structural optimization of rapidly separating microneedles for efficient drug delivery
  Streptozotocin purchased from AbMole

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  RSC Advances. 2017;7:15408-15415.

  A solid polymer microneedle patch pretreatment enhances the permeation of drug molecules into the skin
  Streptozotocin purchased from AbMole

Customer Product Validations & Biological Datas

	Source	Macromol Rapid Commun (2018). Figure 4. Streptozotocin (Abmole Bioscience. USA)
	Method	creating diabetic mice models
	Cell Lines	diabetic mice
	Concentrations	-
	Incubation Time	24 h
	Results	Remarkably, the fluorescence intensity of skin treated by non-crosslinked gelatin MNs decreased more sharply compared with crosslinked RS-PGC-MNs.

	Source	J Drug Target (2018) . Figure 6. Streptozotocin (Abmole Bioscience)
	Method	intraperitoneal injection
	Cell Lines	Balb/c mice
	Concentrations	100 mg/kg
	Incubation Time	48h
	Results	Figure 6(a-b) shows the in-vivo fluorescence images of Balb/c mice after treatment of different molecular weight of PVA, gelatin, chitosan and HA based MNs array at different time (0, 1, 2, 3, 4, 5, and 8 h) intervals of drug release.

	Source	J Ind Eng Chem (2017). Figure 3. Streptozotocin (Abmole Bioscience)
	Method	inject to mice
	Cell Lines	Female Balb/c mice
	Concentrations	10 mg/ml
	Incubation Time	48 h
	Results	The amount of drugs loaded in RSMNs with various length of PLA 182 MNs was approximately 280 ng/patch.

	Source	RSC Advances(2017). Streptozotocin, Figure 7. (AbMole Bioscience, Shanghai, China)
	Method	Prior to the experiment, the diabetic model was induced in BALB/c female mice (6–8 weeks old, 16  0.7 g) with streptozotocin (200 mg/kg in sodium citrate buffer, PH 4.5) administrated by intraperitoneal injection aer they were fasted for 6 h only in case of water.
	Cell Lines
	Concentrations	200 mg/kg
	Incubation Time
	Results

Chemical Information

Molecular Weight	265.22
Formula	C8H15N3O7
CAS Number	18883-66-4
Solubility (25°C)	DMSO >100 mg/mL Water 90 mg/mL
Storage	2-8°C, protect from light, dry, sealed

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Semra Acer, et al. Arq Bras Oftalmol. Oxidative stress of crystalline lens in rat menopausal model

[2] Randa A Hadi Diab, et al. Immunol Lett. Immunotoxicological effects of streptozotocin and alloxan: in vitro and in vivo studies

[3] Yin D, et al. Diabetes. Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen.

[4] Szkudelski T. Physiol Res. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.