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Streptozotocin

Cat. No. M2082
Streptozotocin Structure
Synonym:

Streptozocin, STZ

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
200mg USD 80 In stock
500mg USD 130 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Streptozotocin (Streptozocin, STZ) is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. Streptozotocin specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA. Streptozotocin induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic β-cells in vivo. The effectiveness of STZ depends on the level of GLUT2 expression, which in turn may be influenced by age, sex, strain, or species.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 265.22
Formula C8H15N3O7
CAS Number 18883-66-4
Purity >99%
Solubility DMSO 50 mg/mL
Water 50 mg/mL
Storage at -20°C
Customer Product Validations & Biological Datas
Source Macromol Rapid Commun (2018). Figure 4. Streptozotocin (Abmole Bioscience. USA)
Method creating diabetic mice models
Cell Lines diabetic mice
Concentrations -
Incubation Time 24 h
Results Remarkably, the fluorescence intensity of skin treated by non-crosslinked gelatin MNs decreased more sharply compared with crosslinked RS-PGC-MNs.
Rating
Source J Drug Target (2018) . Figure 6. Streptozotocin (Abmole Bioscience)
Method intraperitoneal injection
Cell Lines Balb/c mice
Concentrations 100 mg/kg
Incubation Time 48h
Results Figure 6(a-b) shows the in-vivo fluorescence images of Balb/c mice after treatment of different molecular weight of PVA, gelatin, chitosan and HA based MNs array at different time (0, 1, 2, 3, 4, 5, and 8 h) intervals of drug release.
Rating
Source J Ind Eng Chem (2017). Figure 3. Streptozotocin (Abmole Bioscience)
Method inject to mice
Cell Lines Female Balb/c mice
Concentrations 10 mg/ml
Incubation Time 48 h
Results The amount of drugs loaded in RSMNs with various length of PLA 182 MNs was approximately 280 ng/patch.
Rating
Source RSC Advances(2017). Streptozotocin, Figure 7. (AbMole Bioscience, Shanghai, China)
Method Prior to the experiment, the diabetic model was induced in BALB/c female mice (6–8 weeks old, 16  0.7 g) with streptozotocin (200 mg/kg in sodium citrate buffer, PH 4.5) administrated by intraperitoneal injection aer they were fasted for 6 h only in case of water.
Cell Lines
Concentrations 200 mg/kg
Incubation Time
Results
Rating
Product Citations
References

Recovery of islet beta-cell function in streptozotocin- induced diabetic mice: an indirect role for the spleen.
Yin D, et al. Diabetes. 2006 Dec;55(12):3256-63. PMID: 17130468.

The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.
Szkudelski T. Physiol Res. 2001;50(6):537-46. PMID: 11829314.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Streptozotocin, Streptozocin, STZ supplier, inhibitors

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