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Mitomycin C

Cat. No. M5791
Mitomycin C Structure
Size Price Availability Quantity
5mg USD 55 In stock
10mg USD 85 In stock
50mg USD 250 In stock
100mg USD 330 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 334.37
Formula C15H18N4O5
CAS Number 50-07-7
Purity >99%
Solubility 66 mg/mL in DMSO
Storage at -20°C
References

Treatment of Refractory Gastrointestinal Strictures With Mitomycin C: A Systematic Review.
Rustagi T, et al. J Clin Gastroenterol. 2015 Nov-Dec;49(10):837-47. PMID: 25626632.

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  Catalog
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Keywords: Mitomycin C supplier, DNA/RNA Synthesis, inhibitors

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