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Mitomycin C

Cat. No. M5791
Mitomycin C Structure
Synonym:

MMC

Size Price Availability Quantity
10mM*1mL in DMSO USD 72  USD80 In stock
5mg USD 49.5  USD55 In stock
10mg USD 76.5  USD85 In stock
50mg USD 220.5  USD245 In stock
100mg USD 297  USD330 In stock
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Quality Control
Biological Activity

Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis.

Product Citations
Customer Product Validations & Biological Datas
Source Int J Mol Sci. 2020 Apr. Figure 9. Mitomycin C (Abmole Bioscience, USA)
Method Wound healing assays
Cell Lines human pancreatic cancer cells (Panc-1)
Concentrations 10 mg/mL
Incubation Time 12 h
Results Leukamenin E induced an inhibitory e ect on the migration of HUVECs and Panc-1 cells using both transwell and wound healing assay.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 334.37
Formula C15H18N4O5
CAS Number 50-07-7
Purity 98.89%
Solubility DMSO 60 mg/mL
Storage -20°C, protect from light, sealed
References

Immunosuppressive properties of mitomycin C-incubated human myeloid blood cells (MIC) in vitro
Laura Dittmar, et al. Hum Immunol. 2015 Jul;76(7):480-7. PMID: 26074415.

Treatment of Refractory Gastrointestinal Strictures With Mitomycin C: A Systematic Review.
Rustagi T, et al. J Clin Gastroenterol. 2015 Nov-Dec;49(10):837-47. PMID: 25626632.

Mitomycin-C-treated peripheral blood mononuclear cells (PBMCs) prolong allograft survival in composite tissue allotransplantation
Christian Andreas Radu, et al. J Surg Res. 2012 Aug;176(2):e95-e101. PMID: 22445458.

Evidence that stimulator cell-derived IL-6 and IL-1 are released in the mixed lymphocyte culture but are not requisite for responder T cell proliferation
P L Leenaerts, et al. Transplantation. 1992 Dec;54(6):1071-8. PMID: 1465772.

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Keywords: Mitomycin C, MMC supplier, DNA/RNA Synthesis, inhibitors

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