Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis.
Biomed Res Int. 2021 Jun 10;2021:6616547.
Int J Mol Sci. 2020 Apr 30;21(9):3164.
Leukamenin E Induces K8/18 Phosphorylation and Blocks the Assembly of Keratin Filament Networks Through ERK Activation
Mitomycin C purchased from AbMole
|Source||Int J Mol Sci. 2020 Apr. Figure 9. Mitomycin C (Abmole Bioscience, USA)|
|Method||Wound healing assays|
|Cell Lines||human pancreatic cancer cells (Panc-1)|
|Incubation Time||12 h|
|Results||Leukamenin E induced an inhibitory e ect on the migration of HUVECs and Panc-1 cells using both transwell and wound healing assay.|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO 60 mg/mL|
|Storage||-20°C, protect from light, sealed|
Immunosuppressive properties of mitomycin C-incubated human myeloid blood cells (MIC) in vitro
Laura Dittmar, et al. Hum Immunol. 2015 Jul;76(7):480-7. PMID: 26074415.
Treatment of Refractory Gastrointestinal Strictures With Mitomycin C: A Systematic Review.
Rustagi T, et al. J Clin Gastroenterol. 2015 Nov-Dec;49(10):837-47. PMID: 25626632.
Mitomycin-C-treated peripheral blood mononuclear cells (PBMCs) prolong allograft survival in composite tissue allotransplantation
Christian Andreas Radu, et al. J Surg Res. 2012 Aug;176(2):e95-e101. PMID: 22445458.
Evidence that stimulator cell-derived IL-6 and IL-1 are released in the mixed lymphocyte culture but are not requisite for responder T cell proliferation
P L Leenaerts, et al. Transplantation. 1992 Dec;54(6):1071-8. PMID: 1465772.
|Related DNA/RNA Synthesis Products|
Beaucage reagent is a potent DNA cleavage agent. Beaucage reagent can be used for preparing phosphorothioate oligomers.
L189 is a novel human DNA ligase inhibitor with IC50s of 5 μM, 9 μM and 5 μM for hLigI, hLigIII and hLigIV, respectively.
Saccharin 1-methylimidazole (also known as SMI) is an activator for DNA and RNA synthesis.
Lurbinectedin, also known as PM01183, is a covalent DNA minor groove binder with potential antineoplastic activity.
|Bleomycin A5 Hydrochloride
Bleomycin A5 Hydrochloride is a unique antibiotic of the bleomycin family that is toxic to eukaryotic and prokaryotic cells.
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