Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis. Mitomycin C (Ametycine) is a DNA cross-linking agent and induces DNA damaging. Mitomycin C is an ADC Cytotoxin and induces apoptosis.
Front Immunol. 2023 May 1;14:1182851.
Inhibition of DAI refrains dendritic cells from maturation and prolongs murine islet and skin allograft survival
Mitomycin C purchased from AbMole
Mol Pharm. 2023 Oct 30.
Extracellular Vesicles Derived from Human Umbilical Cord MSC Improve Vascular Endothelial Function in In Vitro and In Vivo Models of Preeclampsia through Activating Arginine Metabolism
Mitomycin C purchased from AbMole
Immun Inflamm Dis. 2023 Sep;11(9):e1011.
Dendritic cells infected with recombinant adenoviral vector encoding mouse fibroblast activation protein-α and human livin α exert an antitumor effect against Lewis lung carcinoma in mice
Mitomycin C purchased from AbMole
Skin Res Technol. 2023 Feb;29(2):e13290.
The use of human‐derived feeder layers for the cultivation of transplantable human epidermal cell sheet to repair second degree burn wounds
Mitomycin C purchased from AbMole
Comput Math Methods Med. 2022 Jul 13;2022:2517463.
MicroRNA-424-5p Alleviates Isoflurane Anesthesia-Induced Neurotoxicity in Human Embryonic Stem Cell-Derived Neurons by Targeting FASN
Mitomycin C purchased from AbMole
Biomed Res Int. 2021 Jun 10;2021:6616547.
Antioral Squamous Cell Carcinoma Effects of Carvacrol via Inhibiting Inflammation, Proliferation, and Migration Related to Nrf2/Keap1 Pathway
Mitomycin C purchased from AbMole
Int J Mol Sci. 2020 Apr 30;21(9):3164.
Leukamenin E Induces K8/18 Phosphorylation and Blocks the Assembly of Keratin Filament Networks Through ERK Activation
Mitomycin C purchased from AbMole
 |
Source | Int J Mol Sci. 2020 Apr. Figure 9. Mitomycin C (Abmole Bioscience, USA) |
| Method | Wound healing assays | |
| Cell Lines | human pancreatic cancer cells (Panc-1) | |
| Concentrations | 10 ug/mL | |
| Incubation Time | 12 h | |
| Results | Leukamenin E induced an inhibitory e ect on the migration of HUVECs and Panc-1 cells using both transwell and wound healing assay. |
| Molecular Weight | 334.37 |
| Formula | C15H18N4O5 |
| CAS Number | 50-07-7 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage | -20°C, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Animal Modeling Products |
|---|
| Astragalus Polysacharin (70%)
Astragalus Polysacharin is a natural product from Astragalus membranaeus, used as adjuvant, attenuates TNF-α-induced insulin resistance by suppressing miR-721 and activating PPAR-γ and PI3K/Akt in 3T3-L1 adipocytes. |
| Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) is a minor component of CNS myelin. |
| PLP (139-151)
PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE). |
| G6PI 325-339 (human)
G6PI 325-339 (human) is an efficient inducer of arthritis in B10.Q mice. |
| Heparin sodium salt (MW 15kDa)
Heparin sodium salt (MW 15kDa) is a heparin polymer with a molecular weight of 15kDa.Heparin sodium salt is an anticoagulant that reversibly binds to antithrombin III (ATIII), thereby accelerating the rate of inactivation of Thrombin factor IIa and factor Xa by ATIII. Heparin sodium salt is used for blood collection and plasma preparation in experimental animals and for the construction of parenteral nutrition models in mice. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
