Inhibitors
Cat.No. | Name | Information |
---|---|---|
M10080 | Saccharin 1-methylimidazole | Saccharin 1-methylimidazole (also known as SMI) is an activator for DNA and RNA synthesis. |
M10037 | Lurbinectedin | Lurbinectedin, also known as PM01183, is a covalent DNA minor groove binder with potential antineoplastic activity. |
M9860 | Bleomycin A5 Hydrochloride | Bleomycin A5 Hydrochloride is a unique antibiotic of the bleomycin family that is toxic to eukaryotic and prokaryotic cells. |
M9797 | 1-Methyl-3-nitro-1-nitrosoguanidine (MNNG) | Methylnitronitrosoguanidine (MNNG) is an alkylating agent with toxic and mutagenic effects. |
M9786 | Nimustine hydrochloride | Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks. |
M9650 | Triazavirin | Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent, works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments. |
M9527 | BMVC-8C3O | BMVC-8C3O is a DNA G-quadruplexe (G4) ligand which can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s. |
M9506 | TH5487 | TH5487 is a selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. |
M9270 | COH29 | COH29 is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity. |
M9262 | Plicamycin | Plicamycin, also known as mithramycin or Mithramycin A is a n antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. |
M9214 | GC7 Sulfate | GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor. |
M9180 | Pyridostatin Trifluoroacetate Salt | Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer, with a Kd of 490 nM. |
M9118 | Chebulinic acid | Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity. |
M9020 | TAS-102 | TAS-102 is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride. |
M8964 | Thymidine | Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. |
M8490 | 6-Thio-2′-Deoxyguanosine | 6-Thio-2′-deoxyguanosine (6-thio-dG) is a nucleoside analog and telomerase substrate that is incorporated into de novo–synthesized telomeres. |
M8400 | Fialuridine | Fialuridine is a nucleoside analog antiviral agent. |
M7515 | Brivudine | Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication. |
M7506 | 5-methoxyflavone | 5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. |
M6348 | 5-BrdU | 5-BrdU is a synthetic thymidine analog; used for cell proliferation assays. |
M6306 | Madrasin | Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. |
M6264 | Favipiravir | Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections. |
M6053 | Vidarabine | Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses. |
M6046 | Uridine | Uridine is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond. |
M5930 | Rifampicin | Rifampin is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections. |
M5791 | Mitomycin C | Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis. |
M5771 | Mercaptopurine (6-MP) | Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. |
M5767 | Menadione | Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement. |
M5680 | Gemcitabine | Gemcitabine(LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. |
M5648 | Floxuridine | Floxuridine is an antineoplastic antimetabolite, used in the treatment of colon carcinoma and colorectal cancer that has metastasized to the liver. |
M5526 | Clevudine | Clevudine is an antiviral drug for the treatment of hepatitis B. |
M5524 | Cladribine | Cladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively. |
M5375 | 6-Mercaptopurine (6-MP) Monohydrate | 6-Mercaptopurine Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. |
M5300 | Deoxycytidine triphosphate | Deoxycytidine triphosphate (dCTP), a nucleoside triphosphate, is a raw material in DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing. |
M5277 | B02 | B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM). |
M5124 | Mupirocin | Mupirocin is a RNA Synthetase Inhibitor Antibacterial. The mechanism of action of mupirocin is as a RNA Synthetase Inhibitor. |
M4881 | Actinomycin D | Actinomycin d is a bright red rhomboid prisms or red powder. |
M4879 | Cycloheximide | Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM. |
M4807 | SCR7 | SCR7 is a specific DNA Ligase IV inhibitor. |
M4478 | Psoralen | Psoralen(Furocoumarin) is an active ingredient from Fructus Psoraleae; has anticancer activity. |
M3898 | YK-4-279 | YK-4-279 is a potent inhibitor of ETV1 and inhibits both the primary tumor growth and metastasis of fusion positive prostate cancer xenografts. |
M3892 | BMH-21 | BMH-21 is a DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription. |
M3746 | Cyclophosphamide | Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. |
M3742 | Ifosfamide | Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer. |
M3671 | Cyclophosphamide monohydrate | Cyclophosphamide monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA. |
M3661 | Chlorambucil | Chlorambucil is a nitrogen mustard alkylating agent which is mainly used in the treatment of chronic lymphocytic leukemia. |
M3637 | Puromycin dihydrochloride | Puromycin dihydrochloride is an aminonucleoside antibiotic that acts as a protein synthesis inhibitor. |
M3603 | Procarbazine hydrochloride | Procarbazine hydrochloride is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent. |
M3306 | Daphnetin | Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities. |
M3229 | PR-104A | PR-104A is a corresponding alcohol that is systemically converted from PR-104 and a hypoxia-targeted anticancer agent with IC50 of 153 and 60 μM for wild-type CHO AA8 under aerobic and anoxic conditions. |
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