Catalog

DNA/RNA Synthesis DNA/RNA Synthesis

Inhibitors

Cat.No.	Name	Information
M6053	Vidarabine	Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.
M6046	Uridine	Uridine is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.
M5930	Rifampicin	Rifampin is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.
M5791	Mitomycin C	Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers.
M5771	Mercaptopurine (6-MP)	Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
M5767	Menadione	Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.
M5680	Gemcitabine	Gemcitabine(LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.
M5648	Floxuridine	Floxuridine is an antineoplastic antimetabolite, used in the treatment of colon carcinoma and colorectal cancer that has metastasized to the liver.
M5526	Clevudine	Clevudine is an antiviral drug for the treatment of hepatitis B.
M5524	Cladribine	Cladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.
M5375	6-Mercaptopurine (6-MP) Monohydrate	6-Mercaptopurine Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
M5300	Deoxycytidine triphosphate	Deoxycytidine triphosphate (dCTP), a nucleoside triphosphate, is a raw material in DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
M5277	B02	B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM).
M4807	SCR7	SCR7 is a specific DNA Ligase IV inhibitor.
M3898	YK-4-279	YK-4-279 is a potent inhibitor of ETV1 and inhibits both the primary tumor growth and metastasis of fusion positive prostate cancer xenografts.
M3892	BMH-21	BMH-21 is a DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.
M3746	Cyclophosphamide	Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
M3742	Ifosfamide	Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
M3661	Chlorambucil	Chlorambucil is a nitrogen mustard alkylating agent which is mainly used in the treatment of chronic lymphocytic leukemia.
M3637	Puromycin dihydrochloride	Puromycin dihydrochloride is an aminonucleoside antibiotic that acts as a protein synthesis inhibitor.
M3603	Procarbazine hydrochloride	Procarbazine hydrochloride is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent.
M3306	Daphnetin	Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities.
M3229	PR-104A	PR-104A is a corresponding alcohol that is systemically converted from PR-104 and a hypoxia-targeted anticancer agent with IC50 of 153 and 60 μM for wild-type CHO AA8 under aerobic and anoxic conditions.
M3215	Adenine	Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry.
M3214	Adenine hydrochloride	Adenine hydrochloride is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
M3196	CCT239065	CCT239065 is a novel and selective BRAF^V600E and LCK inhibitor with IC50 of 13 nM and 6 nM, respectively.
M3084	Triapine	Triapine is a potent ribonucleotide reductase inhibitor with broad spectrum antitumor activity by inhibiting DNA synthesis.
M2541	CRT0044876	CRT0044876 is a potent and selective APE1 inhibitor with IC50 of ~3 μM.
M2327	Daunorubicin hydrochloride	Daunorubicin HCl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM.
M2293	CX-5461	CX-5461 selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM in HCT-116 cells.
M2292	Cytarabine	Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM.
M2291	Azacitidine	Azacitidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases.
M2290	Oxaliplatin	Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.
M2289	Adrucil	Adrucil(Fluorouracil) belongs to the family of compounds called antimetabolites.
M2288	Carboplatin	Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism.
M2249	Ftorafur	Ftorafur is a chemotherapeutic 5-FU procompound used in the treatment of cancers.
M2247	Carmofur	Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent.
M2224	Raltitrexed	Raltitrexed is an inhibitor of thymidylate synthase used in cancer chemotherapy.
M2223	Cisplatin	Cisplatin is a potent anticancer agent that blocks DNA synthesis.
M2216	Dacarbazine	Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts.
M2100	Bleomycin sulfate	Bleomycin sulfate (Blenoxane) is a glycopeptide antitumor antibiotic isolated from Streptomyces verticillus.
M1963	Capecitabine	Capecitabine (Xeloda, Roche) is an orally-administered chemotherapeutic agent.
M1921	Mizoribine	Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM.
M1916	Nelarabine	Nelarabine is a novel purine antimetabolite antineoplastic agent.

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