Catalog

DNA/RNA Synthesis DNA/RNA Synthesis

Inhibitors

Cat.No.	Name	Information
M9860	Bleomycin A5 Hydrochloride	Bleomycin A5 Hydrochloride is a unique antibiotic of the bleomycin family that is toxic to eukaryotic and prokaryotic cells.
M9797	1-Methyl-3-nitro-1-nitrosoguanidine (MNNG)	Methylnitronitrosoguanidine (MNNG) is an alkylating agent with toxic and mutagenic effects.
M9786	Nimustine hydrochloride	Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks.
M9650	Triazavirin	Triazavirin is a nucleoside analogue of nucleic acid and an antiviral agent, works by inhibiting the synthesis of viral RNA and DNA and replication of genomic fragments.
M9527	BMVC-8C3O	BMVC-8C3O is a DNA G-quadruplexe (G4) ligand which can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s.
M9506	TH5487	TH5487 is a selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM.
M9270	COH29	COH29 is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity.
M9262	Plicamycin	Plicamycin, also known as mithramycin or Mithramycin A is a n antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity.
M9214	GC7 Sulfate	GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor.
M9180	Pyridostatin Trifluoroacetate Salt	Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer, with a Kd of 490 nM.
M9118	Chebulinic acid	Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.
M9020	TAS-102	TAS-102 is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.
M8490	6-Thio-2′-Deoxyguanosine	6-Thio-2′-deoxyguanosine (6-thio-dG) is a nucleoside analog and telomerase substrate that is incorporated into de novo–synthesized telomeres.
M8400	Fialuridine	Fialuridine is a nucleoside analog antiviral agent.
M7515	Brivudine	Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.
M7506	5-methoxyflavone	5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.
M6348	5-BrdU	5-BrdU is a synthetic thymidine analog; used for cell proliferation assays.
M6306	Madrasin	Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly.
M6264	Favipiravir	Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.
M6053	Vidarabine	Vidarabine is an antiviral drug by interfering with the synthesis of viral DNA, used to treat herpes simplex and varicella zoster viruses.
M6046	Uridine	Uridine is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond.
M5930	Rifampicin	Rifampin is a DNA-dependent RNA polymerase inhibitor, used to treat a number of bacterial infections.
M5791	Mitomycin C	Mitomycin C is an antineoplastic antibiotic by inhibiting DNA synthesis.
M5771	Mercaptopurine (6-MP)	Mercaptopurine is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
M5767	Menadione	Menadione(Vitamin K3), a fat-soluble compound, is an inhibitor of Cdc25 phosphatase and mitochondrial DNA polymerase γ (pol γ), used as a nutritional supplement.
M5680	Gemcitabine	Gemcitabine(LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.
M5648	Floxuridine	Floxuridine is an antineoplastic antimetabolite, used in the treatment of colon carcinoma and colorectal cancer that has metastasized to the liver.
M5526	Clevudine	Clevudine is an antiviral drug for the treatment of hepatitis B.
M5524	Cladribine	Cladribine is an adenosine deaminase inhibitor for U266, RPMI8226, and MM1.S cells with IC50 of approximately 2.43 μM, 0.75 μM, and 0.18 μM, respectively.
M5375	6-Mercaptopurine (6-MP) Monohydrate	6-Mercaptopurine Monohydrate is a widely used antileukemic agent and immunosuppressive drug that inhibits de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA.
M5300	Deoxycytidine triphosphate	Deoxycytidine triphosphate (dCTP), a nucleoside triphosphate, is a raw material in DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
M5277	B02	B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM).
M5124	Mupirocin	Mupirocin is a RNA Synthetase Inhibitor Antibacterial. The mechanism of action of mupirocin is as a RNA Synthetase Inhibitor.
M4881	Actinomycin D	Actinomycin d is a bright red rhomboid prisms or red powder.
M4879	Cycloheximide	Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM.
M4807	SCR7	SCR7 is a specific DNA Ligase IV inhibitor.
M4478	Psoralen	Psoralen(Furocoumarin) is an active ingredient from Fructus Psoraleae; has anticancer activity.
M3898	YK-4-279	YK-4-279 is a potent inhibitor of ETV1 and inhibits both the primary tumor growth and metastasis of fusion positive prostate cancer xenografts.
M3892	BMH-21	BMH-21 is a DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription.
M3746	Cyclophosphamide	Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
M3742	Ifosfamide	Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
M3671	Cyclophosphamide monohydrate	Cyclophosphamide monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA.
M3661	Chlorambucil	Chlorambucil is a nitrogen mustard alkylating agent which is mainly used in the treatment of chronic lymphocytic leukemia.
M3637	Puromycin dihydrochloride	Puromycin dihydrochloride is an aminonucleoside antibiotic that acts as a protein synthesis inhibitor.
M3603	Procarbazine hydrochloride	Procarbazine hydrochloride is a hydrochloride salt form of procarbazine which is a polyfunctional alkylating compound used as an antineoplastic agent.
M3306	Daphnetin	Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities.
M3229	PR-104A	PR-104A is a corresponding alcohol that is systemically converted from PR-104 and a hypoxia-targeted anticancer agent with IC50 of 153 and 60 μM for wild-type CHO AA8 under aerobic and anoxic conditions.
M3215	Adenine	Adenine is a purine derivative and a nucleobase with a variety of roles in biochemistry.
M3214	Adenine hydrochloride	Adenine hydrochloride is a hydrochloride salt form of adenine which is a purine derivative and a nucleobase with a variety of roles in biochemistry.
M3196	CCT239065	CCT239065 is a novel and selective BRAF^V600E and LCK inhibitor with IC50 of 13 nM and 6 nM, respectively.

Signaling Pathways

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DNA/RNA Synthesis DNA/RNA Synthesis

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