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Azacitidine

Cat. No. M2291

Azacitidine Structure

Synonym: 5-azacytidine, Mylosar, Ladakamycin

Size Price Availability Quantity
200mg USD 80 In stock
1g USD 250 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Azacitidine (Vidaza) is used in the treatment of myelodysplastic syndrome. Cells in the presence of azacitidine incorporate it into DNA during replication and into RNA during transcription. The incorporation of azacitidine into DNA or RNA inhibits methyltransferase thereby causing demethylation in that sequence, affecting the way that cell regulation proteins are able to bind to the DNA/RNA substrate.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 244.2
Formula C8H12N4O5
CAS Number 320-67-2
Purity >99%
Solubility DMSO 30 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Azacitidine, 5-azacytidine, Mylosar, Ladakamycin supplier, DNA/RNA Synthesis, inhibitors

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