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Cat. No. M2293
CX-5461 Structure
Size Price Availability Quantity
10mg USD 165 In stock
50mg USD 490 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

CX-5461 is a potent small-molecule rRNA synthesis inhibitor with an IC50 of 0.11 μM. CX-5461 selectively blocks RNA PolI transcription,PIC assembly and SL1-rDNA interaction. CX-5461 indicates potent antiproliferative activity in cancer cells and induces autophagy incancer cells. CX-5461 shows potent antitumor activity in A375 and MiaPaca xenografts.

Customer Product Validations & Biological Datas
Source J Exp Clin Cancer Res (2018). Figure 4. CX-5461
Method RT-PCR analysis
Cell Lines GBM cells
Concentrations 1 μM
Incubation Time 48 h
Results CX-5461 could lead to a significant decrease of hTERT-FL in a dose-dependent manner and had no effect on hTERT-All
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 513.61
Formula C27H27N7O2S
CAS Number 1138549-36-6
Purity >98%
Solubility DMSO
Storage at -20°C
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Keywords: CX-5461 supplier, DNA/RNA Synthesis, inhibitors

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