| Cat.No. | Name | Information |
|---|---|---|
| M4879 | Cycloheximide | Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, with IC50 of 532.5 nM. |
| M2129 | Temozolomide | Temozolomide (TMZ) is an oral DNA methylating, chemotherapeutic agent. |
| M2223 | Cisplatin | Cisplatin is an inorganic platinum complex that inhibits DNA synthesis by forming DNA crosslinking agents, inactivates GPXs, reduces cell GSH and induces iron death in HCT116 and A549 cells. |
| M2289 | 5-fluorouracil | 5-fluorouracil (5-FU) is a potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. |
| M2288 | Carboplatin | Carboplatin (NSC 241240) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism. |
| M2292 | Cytarabine | Cytarabine (Cytosine arabinoside, AraC) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM. |
| M1716 | Gemcitabine Hydrochloride | Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM. |
| M5680 | Gemcitabine | Gemcitabine(LY-188011; NSC 613327) is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively. |
| M5277 | B02 | B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM). |
| M7515 | Brivudine | Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication. |
| M10037 | Lurbinectedin | Lurbinectedin, also known as PM01183, is a covalent DNA minor groove binder with potential antineoplastic activity. |
| M9970 | N-Nitrosodiethylamine (NDEA) | N-Nitrosodiethylamine (NDEA) belongs to the nitrosamines category of nitrogenous disinfection byproduct. |
| M9924 | Risdiplam | Risdiplam (also known as RG7916 and RO7034067) is a gene splicing modulator (neuromuscular disease) that distributes into the central nervous system (CNS) and peripheral tissues. |
| M9860 | Bleomycin A5 Hydrochloride | Bleomycin A5 Hydrochloride is a unique antibiotic of the bleomycin family that is toxic to eukaryotic and prokaryotic cells. |
| M9506 | TH5487 | TH5487 is a selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. |
| M9270 | COH29 | COH29 is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity. |
| M9262 | Plicamycin | Plicamycin (Mithramycin A) is a selective specificity protein 1 (Sp1) inhibitor. Plicamycin inhibits the growth of various cancers by decreasing Sp1 protein. Plicamycin has antineoplastic activity. |
| M9214 | GC7 Sulfate | GC7 Sulfate is a deoxyhypusine synthase (DHPS) inhibitor. |
| M9180 | Pyridostatin Trifluoroacetate Salt | Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer, with a Kd of 490 nM. |
| M9179 | Nolatrexed HCl | Nolatrexed HCl, also known as AG337, is a thymidylate synthase inhibitor. |
| M9118 | Chebulinic acid | Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity. |
| M9020 | TAS-102 | TAS-102 is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride. |
| M8960 | LY2334737 | LY2334737 is an orally available valproic acid ester of gemcitabine, a broad-spectrum antimetabolite with antineoplastic activity. |
| M8860 | X80 | X80 is an inhibitor of xeroderma pigmentosum group A protein (XPA protein) required for the removal of all types of DNA lesions repaired by nucleotide excision repair Including both transcription coupled and global genomic nucleotide excision repair. |
| M8672 | CeMMEC13 | CeMMEC13 is a potent inhibitor of the second bromodomain of the transcription initiation factor TAF1 with an an IC50 value of 2. |
| M8555 | Pyrazofurin | Pyrazofurin is an orotidine-5’-monophosphat |
| M8522 | FDI-6 | FDI-6 is a potent and specific inhibitor of FOXM1 that blocks DNA binding. |
| M8490 | 6-Thio-2′-Deoxyguanosine | 6-Thio-2′-deoxyguanosine (6-thio-dG) is a nucleoside analog and telomerase substrate that is incorporated into de novo–synthesized telomeres. |
| M8400 | Fialuridine | Fluuridine is a nucleoside antiviral compound. The compound showed significant mitochondrial toxicity. Fialuridine is also a DNA-directed DNA polymerase inhibitor that may be used to treat HBV infection and has potent activity against hepatitis B virus in vivo and in vitro. FIAU blocks DNA synthesis of human cytomegalovirus, hepatitis B and herpes simplex viruses. |
| M7793 | E3330 | E3330 is a specific inhibitor of AP endonuclease 1 redox domain. |
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