Free shipping on all orders over $ 500

Gemcitabine Hydrochloride

Cat. No. M1716
Gemcitabine Hydrochloride Structure

Gemzar, LY-188011

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 60 In stock
200mg USD 90 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Gemcitabine is an antimetabolites, which inhibits DNA synthesis with an IC50 of 0.06 µM. Gemcitabine is a nucleoside analogue that is incorporated into replicating DNA, resulting in partial chain termination and stalling of replication forks.

Cell Experiment
Cell lines BxPC-3, PANC-1 and PaCa-2 cell lines
Preparation method Cell Counts. The cells were plated in 6-well plates. Twenty-four hours later, the cells were treated with vehicle, gemcitabine, DMAPT, or the combination. After 72 h of treatment, trypan blue-excluded cell counts were performed in duplicate using a hemocytometer. Cell growth was expressed relative to vehicle-treated cells (100 %).
Concentrations 0, 0.005, 0.01, 0.02, 0.04 μM
Incubation time 72 h
Animal Experiment
Animal models MIA PaCa-2 Xenografts model in athymic nude mice
Formulation phosphate-buffered saline, PBS
Dosages a single dose of 50 or 100 mg/kg
Administration intraperitoneal injection
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 299.66
Formula C9H11F2N3O4.HCI
CAS Number 122111-03-9
Purity >98%
Solubility DMSO
Storage at -20°C

Weekly paclitaxel, gemcitabine, and external irradiation followed by randomized farnesyl transferase inhibitor R115777 for locally advanced pancreatic cancer.
Rich et al. Onco Targets Ther. 2012;5:161-70. PMID: 22977306.

Enhancement Of The Antiproliferative Activity Of Gemcitabine By Modulation Of C-Met Pathway In Pancreatic Cancer.
Avan et al. Curr Pharm Des. 2012 Sep 7. PMID: 22973962.

Pilot study of neoadjuvant chemotherapy with gemcitabine and oral S-1 for resectable pancreatic cancer.
Tajima et al. Exp Ther Med. 2012 May;3(5):787-792. PMID: 22969969.

Combination therapy of gemcitabine or oral S-1 with the anti-VEGF monoclonal antibody bevacizumab for pancreatic neuroendocrine carcinoma.
Kasuya et al. Exp Ther Med. 2012 Apr;3(4):599-602. PMID: 22969935.

Dimethylamino parthenolide enhances the inhibitory effects of gemcitabine in human pancreatic cancer cells.
Holcomb BK, et al. J Gastrointest Surg. 2012 Jul;16(7):1333-40. PMID: 22618517.

Related Checkpoint Products

PD0166285 is a potent Wee1 inhibitor and Chk1 inhibitor with IC50s of 24 nM and 72 nM, respectively.

Prexasertib dihydrochloride

Prexasertib dihydrochloride (LY2606368 HCl) is a potent and selective ATP competitive inhibitor of the Chk1 protein kinase with IC50s of <1 nM and 8 nM for CHK1 and CHK2, respectively.


Ipilimumab is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. MW : 148 kD.

CCT241533 hydrochloride

CCT241533 hydrochloride is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM.


CCT241533 is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM.

Abmole Inhibitor Catalog 2017

Keywords: Gemcitabine Hydrochloride, Gemzar, LY-188011 supplier, Checkpoint, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.