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Brivudine

Cat. No. M7515
Brivudine Structure
Synonym:

BVDU

Size Price Availability Quantity
100mg USD 110 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 333.14
Formula C11H13BrN2O5
CAS Number 69304-47-8
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine.
Hew K, et al. PLoS One. 2015 Dec 2;10(12):e0143947. PMID: 26630264.

Brivudin induced delirium: a case report.
Gonen I, et al. J Chemother. 2012 Aug;24(4):229-30. PMID: 23040689.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Brivudine, BVDU supplier, DNA/RNA Synthesis, inhibitors

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