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Brivudine

Cat. No. M7515
Brivudine Structure
Synonym:

BVDU

Size Price Availability Quantity
10mg USD 35  USD35 In stock
25mg USD 50  USD50 In stock
50mg USD 70  USD70 In stock
100mg USD 85  USD85 In stock
200mg USD 130  USD130 In stock
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Quality Control & Documentation
Biological Activity

Brivudine is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. It is incorporated into the viral DNA and blocks the action of DNA polymerases, thus inhibiting viral replication.

Product Citations
Chemical Information
Molecular Weight 333.14
Formula C11H13BrN2O5
CAS Number 69304-47-8
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hew K, et al. PLoS One. Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine.

[2] Gonen I, et al. J Chemother. Brivudin induced delirium: a case report.

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