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Metarrestin (ML246)

Cat. No. M13367
Metarrestin (ML246) Structure
Size Price Availability Quantity
5mg USD 100  USD100 In stock
10mg USD 180  USD180 In stock
25mg USD 360  USD360 In stock
50mg USD 600  USD600 In stock
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Quality Control & Documentation
Biological Activity

Metarrestin (ML246) is a first-in-class, oral active and specific perinucleolar compartment (PNC) inhibitor. It can destroy the nucleolus structure and inhibit the transcription of RNA polymerase (Pol) I. Metarrestin blocks the development of metastasis and prolongs survival in mouse cancer models.

Chemical Information
Molecular Weight 474.6
Formula C31H30N4O
CAS Number 1443414-10-5
Solubility (25°C) DMSO:21 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Margaux J Kanis, et al. Gynecol Oncol Res Pract. A small molecule inhibitor of the perinucleolar compartment, ML246, attenuates growth and spread of ovarian cancer

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