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N-Nitrosodiethylamine (NDEA)

Cat. No. M9970
N-Nitrosodiethylamine (NDEA) Structure
Synonym:

Diaethylnitrosamin; NDMA

Size Price Availability Quantity
5mL USD 110  USD110 In stock
25mL USD 360  USD360 In stock
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Quality Control & Documentation
Biological Activity

N-Nitrosodiethylamine (NDEA) belongs to the nitrosamines category of nitrogenous disinfection byproduct. N-Nitrosodiethylamine has been used to induce hepatocarcinogenesis in rat and mice. NDMA is acted upon by the cytochrome P450 system resulting in the formation of carcinogenic methyldiazonium ion. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

Chemical Information
Molecular Weight 102.14
Formula C4H10N2O
CAS Number 55-18-5
Solubility (25°C) Water 100 mg/mL
DMSO 100 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Devy Maulidya Cahyani, et al. N-nitrosodiethylamine induces inflammation of liver in mice

[2] Masoomeh Mehrnia, et al. Degradation of N-Nitrosodiethylamine in aqueous solution by gamma-irradiation

[3] No authors listed. Rep Carcinog. N-Nitrosodiethylamine

[4] National Toxicology Program. N-Nitrosodiethylamine

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Keywords: N-Nitrosodiethylamine (NDEA), Diaethylnitrosamin; NDMA supplier, DNA/RNA Synthesis, inhibitors, activators


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