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Risdiplam

Cat. No. M9924
Risdiplam Structure
Synonym:

RG7916; RO7034067

Size Price Availability Quantity
5mg USD 150  USD150 In stock
10mg USD 250  USD250 In stock
25mg USD 450  USD450 In stock
50mg USD 880  USD880 In stock
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Quality Control & Documentation
Biological Activity

Risdiplam (also known as RG7916 and RO7034067) is a gene splicing modulator (neuromuscular disease) that distributes into the central nervous system (CNS) and peripheral tissues.

Chemical Information
Molecular Weight 401.46
Formula C22H23N7O
CAS Number 1825352-65-5
Form Solid
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Agnes Poirier, et al. Pharmacol Res Perspect. Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs

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Keywords: Risdiplam, RG7916; RO7034067 supplier, DNA/RNA Synthesis, inhibitors, activators


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