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Cycloheximide

Cat. No. M4879
Cycloheximide Structure
Synonym:

Naramycin A; Actidione

Size Price Availability Quantity
200mg USD 60 In stock
500mg USD 88 In stock
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Quality Control
Biological Activity

Cycloheximide is an inhibitor of protein biosynthesis in eukaryotic organisms, produced by the bacterium Streptomyces griseus. Cycloheximide exerts its effect by interfering with the translocation step in protein synthesis (movement of two tRNA molecules and mRNA in relation to the ribosome) thus blocking translational elongation. Cycloheximide is widely used in biomedical research to inhibit protein synthesis in eukaryotic cells studied in vitro (i.e. outside of organisms). It is inexpensive and works rapidly. Its effects are rapidly reversed by simply removing it from the culture medium.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight
Formula C15H23NO4
CAS Number 66-81-9
Purity >99%
Solubility
Storage at -20°C
Customer Product Validations & Biological Datas
Source Protein and Cell (2016). Figure 4.CHX (ABmole Bioscience, USA)
Method Half-life experiments
Cell Lines Human normal liver cells (LO2)
Concentrations 100 μg/mL
Incubation Time
Results Graph represents collated results rom three independent half-life experiments performed in HEK293, LO2 and HepG2 cells. TIP60 levels were normalized to 1 at time zero.
Rating
Product Citations
References

Prevalence of Dermatophytic Infection and the Spectrum of Dermatophytes in Patients Attending a Tertiary Hospital in Addis Ababa, Ethiopia.
Teklebirhan G,et.al. Int J Microbiol. 2015;653419. PMID: 26448763.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Cycloheximide, Naramycin A; Actidione supplier, inhibitors

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