4-Nitroquinoline N-oxide (4-NQO) corrects DNA damage through nucleotide excision repair. 4NQO may induce DNA damage by generating reactive oxygen species thought to be produced by the enzymatic reduction of its nitro group.
Molecular Weight | 190.16 |
Formula | C9H6N2O3 |
CAS Number | 56-57-5 |
Solubility (25°C) | acetone |
Storage | -20°C, protect from light, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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