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5-fluorouracil

Cat. No. M2289
5-fluorouracil Structure
Synonym:

5-FU, Carac, Efudex; Adrucil

Size Price Availability Quantity
500mg USD 57 In stock
1g USD 65 In stock
2g USD 80 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

5-fluorouracil (5-FU) is a chemotherapy compound that is a pyrimidine analog which is used in the treatment of cancer. 5-fluorouracil (5-FU) works through noncompetitive inhibition of thymidylate synthase. Fluorouracil IC50 values were observed across the National Cancer Institute NCI60 panel of human tumor cell lines, which exhibit a mean IC50 of 17.6 μM, with a range of 1~501 μM.

In vivo, 5-fluorouracil (23 mg/kg, 3 times/week) for 14 days, induces accelerated gastrointestinal transit associated with acute intestinal inflammation at day 3 after the start of treatment, which may have led to persistent changes in the ENS observed after days 7 and 14 of treatment contributing to delayed gastrointestinal transit and colonic dysmotility.

Product Citations
Customer Product Validations & Biological Datas
Source Cancer Biol Ther (2018). Figure 6. 5-FU (Abmole Bioscience, Shanghai, China)
Method Buformin synergizes with chemotherapy
Cell Lines C33A cells
Concentrations 1 μM
Incubation Time
Results In C33A cells, low-dose buformin (1μM) significantly enhanced the anti-proliferative effects when combined with cisplatin, paclitaxel, or 5-FU
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 130.08
Formula C4H3FN2O2
CAS Number 51-21-8
Purity 99.59%
Solubility DMSO 20 mg/mL (Need ultrasonic and warming)
Storage at -20°C
References

Amphiphilic dendritic nanomicelle-mediated co-delivery of 5-fluorouracil and doxorubicin for enhanced therapeutic efficacy.
Han R, et al. J Drug Target. 2017 Feb;25(2):140-148. PMID: 27356094.

Gastrointestinal dysfunction and enteric neurotoxicity following treatment with anticancer chemotherapeutic agent 5-fluorouracil.
McQuade RM, et al. Neurogastroenterol Motil. 2016 Dec;28(12):1861-1875. PMID: 27353132.

Knockdown of NFBD1/MDC1 enhances chemosensitivity to cisplatin or 5-fluorouracil in nasopharyngeal carcinoma CNE1 cells.
Zeng Q, et al. Mol Cell Biochem. 2016 Jul;418(1-2):137-46. PMID: 27334757.

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Keywords: 5-fluorouracil, 5-FU, Carac, Efudex; Adrucil supplier, DNA/RNA Synthesis, inhibitors

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