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Thioguanine

Cat. No. M3258
Thioguanine Structure
Synonym:

6-Thioguanine; 6-TG; 2-Amino-6-mercaptopurine; 2-Amino-6-purinethiol

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
25mg USD 28  USD28 In stock
50mg USD 42  USD42 In stock
100mg USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

The thiopurine compounds are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn’s disease, rheumatoid arthritis) and organ transplant recipients.

Product Citations
Chemical Information
Molecular Weight 167.19
Formula C5H5N5S
CAS Number 154-42-7
Solubility (25°C) DMSO 7 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Femke Crouwel, et al. Thioguanine Therapy in Inflammatory Bowel Diseases. A Practical Guide

[2] Ahmed B Bayoumy, et al. The continuous rediscovery and the benefit-risk ratio of thioguanine, a comprehensive review

[3] Ramya Movva, et al. Critical assessment of thioguanine treatment for inflammatory bowel diseases: Is it time to rehabilitate this treatment?

[4] Kirstin M Taylor, et al. Is there a role for thioguanine therapy in IBD in 2017 and beyond?

[5] Berrie Meijer, et al. Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review

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Keywords: Thioguanine, 6-Thioguanine; 6-TG; 2-Amino-6-mercaptopurine; 2-Amino-6-purinethiol supplier, DNA/RNA Synthesis, inhibitors, activators


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