Free shipping on all orders over $ 500

A 83-01

Cat. No. M5037
A 83-01 Structure
Size Price Availability Quantity
10mg USD 130 In stock
50mg USD 390 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

A-83-01, an inhibitor of TGF-β type I receptor, increased the expression of Myf5 and MyoD, and enhanced myotube formation.The targeting efficacy of single intravenous injections of F-SL combined with A-83-01 was evaluated by measurement of the biodistribution and the antitumor effect in mice bearing murine lung carcinoma M109. A-83-01 temporarily changed the tumor vasculature around 3 h post injection. A-83-01 induced 1.7-fold higher compound accumulation of F-SL in the tumor than liposome alone at 24 h post injection.

Customer Product Validations & Biological Datas
Source Breast Cancer Res Treat (2017). Figure 6. A 83-01
Method MTT assay
Cell Lines SKBR3 cells
Concentrations 1 μM 
Incubation Time 16 h
Results As shown in Fig. 6c that A83-01 alone reduced approximately 17% cell migration of JIMT1 and trastuzumab alone inhibited 20% cell migration, while in combination of A83-01 and trastuzumab synergistically inhibited JIMT1 cell migration up to 90%.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 421.52
Formula C25H19N5S
CAS Number 909910-43-6
Purity >98%
Solubility 40 mM in DMSO
Storage at -20°C
References

Role of endogenous TGF-β family in myogenic differentiation of C2C12 cells.
Furutani Y,et.al. J Cell Biochem. 2011 Feb;614-24. PMID: 21268083.

Enhanced antitumor efficacy of folate-linked liposomal doxorubicin with TGF-β type I receptor inhibitor.
Taniguchi Y,et.al. Cancer Sci. 2010 Oct;2207-13. PMID: 20608940.

Related TGF-beta/Smad Products
ITD-1

ITD-1 is a selective inhibitor of TGF-β signaling (IC50 ~ 0.4-0.8 μM).

R-268712

R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5nM, an approximately 5000-fold more selectivity for ALK5 than p38 mitogen-activated protein kinase (MAPK).

LY3200882

LY3200882 is a novel, highly selective TGFβRI small molecule inhibitor.

SRI-011381 hydrochloride

SRI-011381 hydrochloride is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.

Disitertide

Disitertide is a TGF-β1 inhibitor.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: A 83-01 supplier, TGF-beta/Smad, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.