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A 83-01

Cat. No. M5037
A 83-01 Structure
Size Price Availability Quantity
10mg USD 130 In stock
50mg USD 400 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

A-83-01, an inhibitor of TGF-β type I receptor, increased the expression of Myf5 and MyoD, and enhanced myotube formation.The targeting efficacy of single intravenous injections of F-SL combined with A-83-01 was evaluated by measurement of the biodistribution and the antitumor effect in mice bearing murine lung carcinoma M109. A-83-01 temporarily changed the tumor vasculature around 3 h post injection. A-83-01 induced 1.7-fold higher compound accumulation of F-SL in the tumor than liposome alone at 24 h post injection.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 421.52
Formula C25H19N5S
CAS Number 909910-43-6
Purity >99%
Solubility 50 mM in DMSO
Storage at -20°C
References

Role of endogenous TGF-β family in myogenic differentiation of C2C12 cells.
Furutani Y,et.al. J Cell Biochem. 2011 Feb;614-24. PMID: 21268083.

Enhanced antitumor efficacy of folate-linked liposomal doxorubicin with TGF-β type I receptor inhibitor.
Taniguchi Y,et.al. Cancer Sci. 2010 Oct;2207-13. PMID: 20608940.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: A 83-01 supplier, TGF-beta, inhibitors

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