Erastin

Biological Activity

Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3).

*The compound is unstable in solutions, freshly prepared is recommended

Product Citations

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  Int J Biol Macromol. 2025 Mar 22.

  The glutamine starvation-induced lncRNA FERRIN suppresses ferroptosis via the stabilization of SLC7A11 mRNA
  Erastin purchased from AbMole

• 

  Phytomedicine. 2025 May 17; .

  Celastrol Attenuates Ferroptosis-Mediated Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury via Hippo-YAP Signaling
  Erastin purchased from AbMole

• 

  Life Sci. 2025 Jan 28;1:364:123433.

  Inhibition of NSUN6 protects against intermittent hypoxia-induced oxidative stress and inflammatory response in adipose tissue through suppressing macrophage ferroptosis and M1 polarization
  Erastin purchased from AbMole

• 

  J Cancer. 2025 Jan 01;16(2):417-429.

  TYMS Enhances Colorectal Cell Antioxidant Capacity Via the KEAP1-NRF2 Pathway to Resist Ferroptosis
  Erastin purchased from AbMole

• 

  Cell Metab. 2024 Nov 01.

  Microbiota-derived lysophosphatidylcholine alleviates Alzheimer’s disease pathology via suppressing ferroptosis
  Erastin purchased from AbMole

• 

  Sci Total Environ. 2024 Nov 15;951:175612.

  SAP130 mediates crosstalk between hepatocyte ferroptosis and M1 macrophage polarization in PFOS-induced hepatotoxicity
  Erastin purchased from AbMole

• 

  Phytomedicine. 2024 Sep 27.

  Naringenin alleviates intestinal ischemia/reperfusion injury by inhibiting ferroptosis via targeting YAP/STAT3 signaling axis
  Erastin purchased from AbMole

• 

  Cell Biol Toxicol. 2024 Dec 21;41(1):14.

  NMF typing and machine learning algorithm-based exploration of preeclampsia-related mechanisms on ferroptosis signature genes
  Erastin purchased from AbMole

• 

  JPI. 2024 Jan-Feb;67(1):p 47-56.

  Fatty Acid Binding Protein-4 Silencing Inhibits Ferroptosis to Alleviate Lipopolysaccharide-induced Injury of Renal Tubular Epithelial Cells by Blocking Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling
  Erastin purchased from AbMole

• 

  Asian Journal of Pharmaceutical Sciences. 2023 Nov.

  Mechanistic engineering of celastrol liposomes induces ferroptosis and apoptosis by directly targeting VDAC2 in hepatocellular carcinoma
  Erastin purchased from AbMole

• 

  Oxid Med Cell Longev. 2023 Jan 14;2023:6896790.

  Curcumin Induces Ferroptosis in Follicular Thyroid Cancer by Upregulating HO-1 Expression
  Erastin purchased from AbMole

• 

  Cancer Cell Int. 2023 Jan 13;23(1):5.

  Heat shock protein 27 deficiency promotes ferrous ion absorption and enhances acyl-Coenzyme A synthetase long-chain family member 4 stability to promote
  Erastin purchased from AbMole

• 

  Apoptosis. 2023 Apr;28(3-4):607-626.

  Inhibition of ferroptosis by icariin treatment attenuates excessive ethanol consumption-induced atrial remodeling and susceptibility to atrial fibrillation, role of SIRT1
  Erastin purchased from AbMole

• 

  Arthritis Res Ther. 2023 Oct 26;25(1):212.

  ACSL4 inhibition prevents macrophage ferroptosis and alleviates fibrosis in bleomycin-induced systemic sclerosis model
  Erastin purchased from AbMole

• 

  Oxid Med Cell Longev. 2022 Apr 16;2022:4505513.

  Nrf2-Mediated Ferroptosis Inhibition Exerts a Protective Effect on Acute-on-Chronic Liver Failure
  Erastin purchased from AbMole

• 

  Front Pharmacol. 2022 Oct 18;13:1026641.

  Platelet-rich plasma ameliorates lipopolysaccharide-induced cardiac injury by inflammation and ferroptosis regulation
  Erastin purchased from AbMole

• 

  J Clin Invest. 2021 Nov 15;131(22):e152067.

  RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11
  Erastin purchased from AbMole

• 

  Patent. CN113499440A 2021 Oct 15.

  Patent. CN113499440A
  Erastin purchased from AbMole

Chemical Information

Molecular Weight	547.04
Formula	C30H31ClN4O4
CAS Number	571203-78-6
Solubility (25°C)	DMSO ≥ 10 mg/mL (Need ultrasonic)
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Yu-Ting Bai, et al. Int J Med Sci. Hypoxia protects H9c2 cells against Ferroptosis through SENP1-mediated protein DeSUMOylation

[2] Jing Du, et al. Redox Biol. Identification of Frataxin as a regulator of ferroptosis

[3] Yan Yu, et al. Mol Cell Oncol. The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents

[4] Y Xie, et al. Cell Death Differ. Ferroptosis: process and function

[5] Scott J Dixon, et al. Cell. Ferroptosis: an iron-dependent form of nonapoptotic cell death