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Erastin

Cat. No. M2679
Erastin Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
2mg USD 50  USD50 In stock
5mg USD 90  USD90 In stock
10mg USD 170  USD170 In stock
50mg USD 480  USD480 In stock
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Quality Control
Biological Activity

Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3). 

*The compound is unstable in solutions, freshly prepared is recommended

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 547.04
Formula C30H31ClN4O4
CAS Number 571203-78-6
Purity 99.40%
Solubility DMSO ≥ 10 mg/mL (Need ultrasonic)
Storage at -20°C
References

[1] Jing Du, et al. Redox Biol. Identification of Frataxin as a regulator of ferroptosis

[2] Yan Yu, et al. Mol Cell Oncol. The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents

[3] Y Xie, et al. Cell Death Differ. Ferroptosis: process and function

[4] Scott J Dixon, et al. Cell. Ferroptosis: an iron-dependent form of nonapoptotic cell death

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Erastin supplier, Ferroptosis, inhibitors

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