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Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. Erastin is a ferroptosis inducer. Erastin binds and inhibits voltage-dependent anion channels (VDAC2/VDAC3).
*The compound is unstable in solutions, freshly prepared is recommended
J Clin Invest. 2021 Nov 15;131(22):e152067.
RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11
Erastin purchased from AbMole
J Clin Invest. 2021 Nov 15;131(22):e152067.
RBMS1 regulates lung cancer ferroptosis through translational control of SLC7A11
Erastin purchased from AbMole
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 547.04 |
| Formula | C30H31ClN4O4 |
| CAS Number | 571203-78-6 |
| Purity | 99.40% |
| Solubility | DMSO ≥ 10 mg/mL (Need ultrasonic) |
| Storage | at -20°C |
[1] Jing Du, et al. Redox Biol. Identification of Frataxin as a regulator of ferroptosis
[3] Y Xie, et al. Cell Death Differ. Ferroptosis: process and function
[4] Scott J Dixon, et al. Cell. Ferroptosis: an iron-dependent form of nonapoptotic cell death
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