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Lipopolysaccharides

Cat. No. M9524
Lipopolysaccharides Structure
Synonym:

LPS

Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 160  USD160 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity Potency ≥ 500000 EU/mg
  • COA
  • MSDS
Biological Activity

Lipopolysaccharides (LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharide is a highly immunogenic antigen which can enhance immune responses. This product is derived from Escherichia coli O55:B5. Its potency is more than 500,000 EU/mg.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity Potency ≥ 500000 EU/mg
Solubility Water ≥ 5 mg/mL
Storage 2-8°C, dry, protect from light, sealed
References

[1] Hai-Ping Zhu, et al. Mol Med Rep. Regulatory mechanism of NOV/CCN3 in the inflammation and apoptosis of lung epithelial alveolar cells upon lipopolysaccharide stimulation

[2] Lei Yang, et al. Am J Transl Res. Resveratrol alleviates sepsis-induced acute lung injury by suppressing inflammation and apoptosis of alveolar macrophage cells

[3] H T L Lai, et al. Poult Sci. Effects of Repeated Intratracheally Administered Lipopolysaccharide on Primary and Secondary Specific Antibody Responses and on Body Weight Gain of Broilers.

[4] D S Kabanov, et al. Biochemistry (Mosc). Structural Analysis of Lipopolysaccharides From Gram-negative Bacteria.

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Keywords: Lipopolysaccharides, LPS supplier, Immunology/Inflammation, inhibitors

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