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Bafilomycin A1

Cat. No. M4953

Bafilomycin A1 Structure

Synonym: Baf-A1

Size Price Availability
100 μg USD 80 Custom Synthesis
500 μg USD 320 Custom Synthesis
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Quality Control
  • Current batch:
  • Purity >95%
  • COA
  • MSDS
Biological Activity

Bafilomycin A1 is a toxic macrolide antibiotic derived from Streptomyces griseus. Bafilomycin A1 inhibits the short circuit current induced by the outer mantle epithelium (OME). The IC50 and maximum inhibition dose of Bafilomycin A1 are 0.17 μM and 0.5 μM, respectively. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. (V-ATPase). The most used bafilomycin is bafilomycin A1. This is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 622.83
Formula C35H58O9
CAS Number 88899-55-2
Purity >95%
Solubility DMSO
Water
Storage at -20°C
References

H+-ATPase of crude homogenate of the outer mantle epithelium of Anodonta cygnea.
Oliveira PF, et al. Comp Biochem Physiol A Mol Integr Physiol. 2004 Dec;139(4):425-32. PMID: 15596387.

Characterization of ATPases of apical membrane fractions from Locusta migratoria Malpighian tubules.
al-Fifi ZI, et al. Insect Biochem Mol Biol. 1998 Apr;28(4):201-11. PMID: 9684329.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Bafilomycin A1, Baf-A1 supplier, Proton Pump, inhibitors

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