Sulforaphane inhibits the lipopolysaccharide LPS induced HDAC6, HDAC10 and DNA methyltransferase (DNMT3a) gene expression, whereas up-regulated the expression of DNMT1 gene.Sulforaphane inhibits the global HDAC activity, and suppressed moDCs differentiation from immature to mature DCs through down-regulating the CD40, CD80 and CD86 expression and led further to enhanced phagocytosis of moDCs.Sulforaphane showed a protective role in LPS induced cell apoptosis through suppressing the IRF6 and TGF-ß1 production. Sulforaphane impaired the pro-inflammatory cytokine TNF-α and IL-1ß secretion into the cell culture supernatants that were induced in moDCs by LPS stimulation, whereas Sulforaphane increased the cellular-resident TNF-α accumulation.Sulforaphane plays a protective role against APAP-mediated hepatotoxicity through antioxidant effects mediated by HO-1 induction. Sulforaphane has preventive action in oxidative stress-mediated liver injury.Sulforaphane has the potential to improve cognitive function in patients with schizophrenia.Sulforaphane protected cells against glycative damage by inhibiting the activation of caspase-3 enzyme, reducing the phosphorylation of MAPK signaling pathways (ERK1/2, JNK, and p38), reducing oxidative stress and increasing intracellular GSH levels.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Neuroprotective effect of sulforaphane against methylglyoxal cytotoxicity.
Angeloni C, et al. Chem Res Toxicol. 2015 May 1. PMID: 25933243.
The effects of sulforaphane on the liver and remote organ damage in hepatic ischemia-reperfusion model formed with pringle maneuver in rats.
Oguz A, et al. Int J Surg. 2015 Apr 26. PMID: 25924817.
An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients with Schizophrenia.
Shiina A, et al. Clin Psychopharmacol Neurosci. 2015 Apr 30;13(1):62-7. PMID: 25912539.
Sulforaphane protects against acetaminophen-induced hepatotoxicity.
Noh JR, et al. Food Chem Toxicol. 2015 Mar 25;80:193-200. PMID: 25818464.
Sulforaphane epigenetically regulates innate immune responses of porcine monocyte-derived dendritic cells induced with lipopolysaccharide.
Qu X, et al. PLoS One. 2015 Mar 20;10(3):e0121574. PMID: 25793534.
|Related HDAC Products|
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Biphenyl-4-sulfonyl chloride is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation.
ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM.
HPOB is a highly potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 56 nM, >30 fold less potent against other HDACs.
HDAC8-IN-1 is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines.
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