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Sulforaphane

Cat. No. M3988

Sulforaphane Structure

Synonym: SFN

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Sulforaphane inhibits the lipopolysaccharide LPS induced HDAC6, HDAC10 and DNA methyltransferase (DNMT3a) gene expression, whereas up-regulated the expression of DNMT1 gene.Sulforaphane inhibits the global HDAC activity, and suppressed moDCs differentiation from immature to mature DCs through down-regulating the CD40, CD80 and CD86 expression and led further to enhanced phagocytosis of moDCs.Sulforaphane showed a protective role in LPS induced cell apoptosis through suppressing the IRF6 and TGF-ß1 production. Sulforaphane impaired the pro-inflammatory cytokine TNF-α and IL-1ß secretion into the cell culture supernatants that were induced in moDCs by LPS stimulation, whereas Sulforaphane increased the cellular-resident TNF-α accumulation.Sulforaphane plays a protective role against APAP-mediated hepatotoxicity through antioxidant effects mediated by HO-1 induction. Sulforaphane has preventive action in oxidative stress-mediated liver injury.Sulforaphane has the potential to improve cognitive function in patients with schizophrenia.Sulforaphane protected cells against glycative damage by inhibiting the activation of caspase-3 enzyme, reducing the phosphorylation of MAPK signaling pathways (ERK1/2, JNK, and p38), reducing oxidative stress and increasing intracellular GSH levels.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 177.29
Formula C6H11NOS2
CAS Number 4478-93-7
Purity >99%
Solubility Ethanol
Storage at -20°C
References

Neuroprotective effect of sulforaphane against methylglyoxal cytotoxicity.
Angeloni C, et al. Chem Res Toxicol. 2015 May 1. PMID: 25933243.

The effects of sulforaphane on the liver and remote organ damage in hepatic ischemia-reperfusion model formed with pringle maneuver in rats.
Oguz A, et al. Int J Surg. 2015 Apr 26. PMID: 25924817.

An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients with Schizophrenia.
Shiina A, et al. Clin Psychopharmacol Neurosci. 2015 Apr 30;13(1):62-7. PMID: 25912539.

Sulforaphane protects against acetaminophen-induced hepatotoxicity.
Noh JR, et al. Food Chem Toxicol. 2015 Mar 25;80:193-200. PMID: 25818464.

Sulforaphane epigenetically regulates innate immune responses of porcine monocyte-derived dendritic cells induced with lipopolysaccharide.
Qu X, et al. PLoS One. 2015 Mar 20;10(3):e0121574. PMID: 25793534.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Sulforaphane, SFN supplier, HDAC, inhibitors

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