Sulforaphane inhibits the lipopolysaccharide LPS induced HDAC6, HDAC10 and DNA methyltransferase (DNMT3a) gene expression, whereas up-regulated the expression of DNMT1 gene.Sulforaphane inhibits the global HDAC activity, and suppressed moDCs differentiation from immature to mature DCs through down-regulating the CD40, CD80 and CD86 expression and led further to enhanced phagocytosis of moDCs.Sulforaphane showed a protective role in LPS induced cell apoptosis through suppressing the IRF6 and TGF-ß1 production. Sulforaphane impaired the pro-inflammatory cytokine TNF-α and IL-1ß secretion into the cell culture supernatants that were induced in moDCs by LPS stimulation, whereas Sulforaphane increased the cellular-resident TNF-α accumulation.Sulforaphane plays a protective role against APAP-mediated hepatotoxicity through antioxidant effects mediated by HO-1 induction. Sulforaphane has preventive action in oxidative stress-mediated liver injury.Sulforaphane has the potential to improve cognitive function in patients with schizophrenia.Sulforaphane protected cells against glycative damage by inhibiting the activation of caspase-3 enzyme, reducing the phosphorylation of MAPK signaling pathways (ERK1/2, JNK, and p38), reducing oxidative stress and increasing intracellular GSH levels.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Neuroprotective effect of sulforaphane against methylglyoxal cytotoxicity.
Angeloni C, et al. Chem Res Toxicol. 2015 May 1. PMID: 25933243.
The effects of sulforaphane on the liver and remote organ damage in hepatic ischemia-reperfusion model formed with pringle maneuver in rats.
Oguz A, et al. Int J Surg. 2015 Apr 26. PMID: 25924817.
An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients with Schizophrenia.
Shiina A, et al. Clin Psychopharmacol Neurosci. 2015 Apr 30;13(1):62-7. PMID: 25912539.
Sulforaphane protects against acetaminophen-induced hepatotoxicity.
Noh JR, et al. Food Chem Toxicol. 2015 Mar 25;80:193-200. PMID: 25818464.
Sulforaphane epigenetically regulates innate immune responses of porcine monocyte-derived dendritic cells induced with lipopolysaccharide.
Qu X, et al. PLoS One. 2015 Mar 20;10(3):e0121574. PMID: 25793534.
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BRD73954 ia a potent and selective HDAC inhibitor with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.
Sodium butyrate is the sodium salt of butyric acid, which has been reported to cause hyperacetylation of histones due to its role as a HDAC inhibitor with IC50 values of 0.3, 0.4, 0.3 mM for HDAC1, 2 and 7 respectively.
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