Deferoxamine mesylate as a chelating agent used to remove excess iron from the body, treat acute iron poisoning, especially in small children, used to treat hemochromatosis, that can be either genetic or acquired.
Metallomics. 2018 Aug 24.
Iron depletion participates in the suppression of cell proliferation induced by lipin1 overexpression.
Deferoxamine mesylate purchased from AbMole
|Source||The Royal Society of Chemistry (2018 Aug). Figure 1. Deferoxamine (Abmole Bioscience)|
|Method||Cell viability assay|
|Cell Lines||Empty vector cells|
|Incubation Time||24, 48 and 72 h|
|Results||Herein, we found that DFO inhibited the growth of human BEL7402 cells in a dose and time dependent manner.|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||33 mg/mL in water|
The clinical effect of deferoxamine mesylate on edema after intracerebral hemorrhage.
Yu Y, et al. PLoS One. 2015 Apr 13;10(4):e0122371. PMID: 25875777.
cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA.
N6-isopentenyladenosine is a plant hormone.
X-α-Gal is suitable as a substrate for α-galactosidase.
RU320521 (also known as RU521; RU.521) is a potent and selective inhibitor of cGAS, inhibiting cGAS-mediated interferon upregulation.
|Dextran sulfate sodium salt
Dextran sulfate sodium salt is a polyanionic derivative of dextran produced by esterification of Dextran with chlorosulphonic acid.
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