Deferoxamine mesylate as a chelating agent used to remove excess iron from the body, treat acute iron poisoning, especially in small children, used to treat hemochromatosis, that can be either genetic or acquired.
Metallomics. 2018 Aug 24.
Iron depletion participates in the suppression of cell proliferation induced by lipin1 overexpression.
Deferoxamine mesylate purchased from AbMole
|Source||The Royal Society of Chemistry (2018 Aug). Figure 1. Deferoxamine (Abmole Bioscience)|
|Method||Cell viability assay|
|Cell Lines||Empty vector cells|
|Incubation Time||24, 48 and 72 h|
|Results||Herein, we found that DFO inhibited the growth of human BEL7402 cells in a dose and time dependent manner.|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||33 mg/mL in water|
The clinical effect of deferoxamine mesylate on edema after intracerebral hemorrhage.
Yu Y, et al. PLoS One. 2015 Apr 13;10(4):e0122371. PMID: 25875777.
S107 is a Type 1 ryanodine receptor (RyR1) stabilizer.
3,3’,5,5’-Tetramethylbenzidine(TMB) is a chromogenic substrate used in staining procedures in immunohistochemistry as well as being a visualising reagent used in enzyme-linked immunosorbent assays (ELISA).
Coelenterazine is the luciferin, the light-emitting molecule, used for monitoring reporter genes in BRET, ELISA and HTS techniques.
Fluorescein is a synthetic organic compound and dye.
SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.
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