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Deferoxamine mesylate

Cat. No. M5558
Deferoxamine mesylate Structure
Synonym:

Desferrioxamine B mesylate; DFOM

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM/1mL In DMSO USD 62 In stock
100mg USD 120 In stock
500mg USD 260 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Deferoxamine mesylate as a chelating agent used to remove excess iron from the body, treat acute iron poisoning, especially in small children, used to treat hemochromatosis, that can be either genetic or acquired.

Product Citations
Customer Product Validations & Biological Datas
Source The Royal Society of Chemistry (2018 Aug). Figure 1. Deferoxamine (Abmole Bioscience)
Method Cell viability assay
Cell Lines Empty vector cells
Concentrations 0-1600 mM
Incubation Time 24, 48 and 72 h
Results Herein, we found that DFO inhibited the growth of human BEL7402 cells in a dose and time dependent manner.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 656.79
Formula C26H52N6O11S
CAS Number 138-14-7
Purity >98%
Solubility 33 mg/mL in water
Storage at -20°C
References

The clinical effect of deferoxamine mesylate on edema after intracerebral hemorrhage.
Yu Y, et al. PLoS One. 2015 Apr 13;10(4):e0122371. PMID: 25875777.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Deferoxamine mesylate, Desferrioxamine B mesylate; DFOM supplier, inhibitors

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