Deferoxamine mesylate as a chelating agent used to remove excess iron from the body, treat acute iron poisoning, especially in small children, used to treat hemochromatosis, that can be either genetic or acquired.
Metallomics. 2018 Aug 24.
Iron depletion participates in the suppression of cell proliferation induced by lipin1 overexpression.
Deferoxamine mesylate purchased from AbMole
|Source||The Royal Society of Chemistry (2018 Aug). Figure 1. Deferoxamine (Abmole Bioscience)|
|Method||Cell viability assay|
|Cell Lines||Empty vector cells|
|Incubation Time||24, 48 and 72 h|
|Results||Herein, we found that DFO inhibited the growth of human BEL7402 cells in a dose and time dependent manner.|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||33 mg/mL in water|
The clinical effect of deferoxamine mesylate on edema after intracerebral hemorrhage.
Yu Y, et al. PLoS One. 2015 Apr 13;10(4):e0122371. PMID: 25875777.
Phytohemagglutinin is a lectin obtained from the red kidney bean that binds to the membranes of T-cells, stimulates metabolic activity and involves inflammatory pathways.
Apilimod is a potent IL-12/IL-23 inhibitor, and it is also a cell permeable small molecule which specifically inhibits PIKfyve with an IC50 of 14 nM in an in vitro kinase assay.
10-Hydroxy-trans-2-decenoic acid is the principal lipid component in royal jelly which is the food for queen and larvae honeybees.
Brij-35 (Polidocanol) is a high HLB, ethoxylated, nonionic ether of lauryl alcohol with broad pH stability.
Hyaluronic acid (HA) is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues.
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