Deferoxamine mesylate as a chelating agent used to remove excess iron from the body, treat acute iron poisoning, especially in small children, used to treat hemochromatosis, that can be either genetic or acquired.
Metallomics. 2018 Aug 24.
Iron depletion participates in the suppression of cell proliferation induced by lipin1 overexpression.
Deferoxamine mesylate purchased from AbMole
|Source||The Royal Society of Chemistry (2018 Aug). Figure 1. Deferoxamine (Abmole Bioscience)|
|Method||Cell viability assay|
|Cell Lines||Empty vector cells|
|Incubation Time||24, 48 and 72 h|
|Results||Herein, we found that DFO inhibited the growth of human BEL7402 cells in a dose and time dependent manner.|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||33 mg/mL in water|
The clinical effect of deferoxamine mesylate on edema after intracerebral hemorrhage.
Yu Y, et al. PLoS One. 2015 Apr 13;10(4):e0122371. PMID: 25875777.
Apilimod mesylate is a potent IL-12/IL-23 inhibitor, which inhibits the IL-12 production in cultures of IFN-γ/LPS–stimulated human PBMCs with an IC50 of 10 nM.
OK432 is a freeze-dried vaccine.
IACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS).
Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.
Glycochenodeoxycholic acid (Chenodeoxycholylglycine) is a bile acid formed in the liver from chenodeoxycholate and glycine.
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