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Puromycin dihydrochloride

Cat. No. M3637
Puromycin dihydrochloride Structure
Synonym:

Puromycin 2HCl

Size Price Availability Quantity
25mg USD 100 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Puromycin dihydrochloride is a protein synthesis inhibitor. Puromycin 2HCl leads to the premature release of polypeptide chains as polypeptidyl purine derivatives. Analog of the 3' end of aminoacyl-tRNA. Puromycin dihydrochloride Inhibits translation in both in vitro and in vivo systems. Puromycin dihydrochloride inhibits the transport of proteins into the mitochondria in vitro. Puromycin inhibits protein import into mitochondria by interfering with an ATP-dependent step in the import process and that the ATP-dependent component in the reaction is located inside the inner mitochondrial membrane.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 544.43
Formula C22H29N7O5.2HCl
CAS Number 58-58-2
Purity >98%
Solubility DMSO
Storage at -20°C
References

Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction.
Price J, et al. Biochim Biophys Acta. 1993 Jul 25;1150(1):89-97. PMID: 8334141.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Puromycin dihydrochloride, Puromycin 2HCl supplier, DNA/RNA Synthesis, inhibitors

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