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Mdivi-1

Cat. No. M2830
Mdivi-1 Structure
Synonym:

Mitochondrial division inhibitor 1

Size Price Availability Quantity
5mg USD 40  USD40 In stock
10mg USD 60  USD60 In stock
50mg USD 200  USD200 In stock
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Quality Control
Biological Activity

Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 353.22
Formula C15H10Cl2N2O2S
CAS Number 338967-87-6
Purity 98.76%
Solubility DMSO 55 mg/mL
Storage at -20°C
Related Dynamin Products
Dynasore

Dynasore is a cell-permeable, reversible non-competitive dynamin inhibitor of GTPase activity of dynamin 1/2, with IC50 of 15 μM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Mdivi-1, Mitochondrial division inhibitor 1 supplier, Dynamin, inhibitors

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