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2-Deoxy-D-glucose

Cat. No. M5140
2-Deoxy-D-glucose Structure
Synonym:

2-DG

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
200mg USD 30  USD30 In stock
500mg USD 45  USD45 In stock
1g USD 60  USD60 In stock
5g USD 150  USD150 In stock
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Quality Control
Biological Activity

Across all 16 tumor cell lines, there was a significant correlation between DG uptake and 3-O-MG transport (p = 0.0012, F test), but not between DG uptake and hexokinase activity. Hexokinase activity of the tumor cells was comparable to that of the human fibroblast cells in the exponential growth phase. Most tumor cells showed higher DG uptake and 3-O-MG transport than the human fibroblast cells.The 2DG6P content in isolated rat soleus muscle after incubation with 2-deoxyglucose (2DG) was increased in a dose-dependent manner by insulin (ED(50) = 0.6 mU/ml), the maximum response being about 5 times that of the basal content in vitro.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 164.16
Formula C6H12O5
CAS Number 154-17-6
Purity >99%
Solubility Water 30 mg/mL
DMSO 15 mg/mL
Storage at -20°C
References

[1] Ueyama A,et.al. Biol Signals Recept Nonradioisotope assay of glucose uptake activity in rat skeletal muscle using enzymatic measurement of 2-deoxyglucose 6-phosphate in vitro and in vivo.

[2] Waki A,et.al. Nucl Med Biol The importance of glucose transport activity as the rate-limiting step of 2-deoxyglucose uptake in tumor cells in vitro.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 2-Deoxy-D-glucose, 2-DG supplier, inhibitors

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