| Cat.No. | Name | Information |
|---|---|---|
| M58991 | Phenazopyridine | Phenazopyridine is a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine is a TRPM8 antagonist. Phenazopyridine can promote neuronal differentiation and it can also be used in the research of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases. |
| M58990 | CZ-48 | CZ-48 (Sulfo-ara-F-NMN) is a mimetic of nicotinamide mononucleotide (NMN). CZ-48 acts selectively, activating SARM1 but inhibiting CD38 (IC50 around 10 μM). CZ-48 induces intracellular cyclic ADP-ribose (cADPR) production. |
| M58989 | 5-Iodoisoquinoline | 5-Iodoisoquinoline is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. 5-Iodoisoquinoline is selective against other NAD+-processing enzymes, receptors, and transporters. |
| M58988 | Gadoteric acid | Gadoteric acid is a macrocyclic, paramagnetic, gadolinium-based contrast agent that can be used for magnetic resonance imaging (MRI) of the brain, spine, and related tissues. Gadoteric acid is able to detect and visualize areas of blood-brain barrier disruption and abnormal vascular distribution. |
| M58987 | 4-MUNANA | 4-MUNANA is a substrate of influenza virus neuraminidase (NA) with high selectivity and irreversible reaction. In the enzymatic reaction, 4-MUNANA is hydrolyzed by NA to generate fluorescent 4-methylumbelliferone (4-MU). By detecting the fluorescence intensity of 4-MU, quantitative analysis of NA activity can be achieved. |
| M58986 | Sulfo-SANPAH | Sulfo-SANPAH is a primary amine-nitrobenzene azide cross-linker. Sulfo-SANPAH is a heterobifunctional crosslinker that contain an amine-reactive N-hydroxysuccinimide (NHS) ester and a photoactivatable nitrophenyl azide. |
| M58984 | Glembatumumab vedotin | Glembatumumab vedotin (CDX-011) is an antibody-drug conjugate (ADC) comprising a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB) and conjugated to the potent tubulinbinding cytotoxic agent MMAE via a protease-sensitive vc linker. Glembatumumab vedotin has potent anticancer effects. |
| M58983 | Denintuzumab-MMAF | Denintuzumab-MMAF is an antibody-drug conjugate (ADC). Codrituzumab is a monoclonal antibody targeting GPC3 (glypican-3). Denintuzumab (hBU 12) is a recombinant humanized anti-CD19 monoclonal antibody. Denintuzumab binds to CD19 on the surface of B cells. |
| M58982 | Enapotamab vedotin | Enapotamab vedotin is an AXL-targeted antibody-drug conjugate (ADC) with inhibitory potential against high AXL expressing non-small cell lung cancer (NSCLC). |
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