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5-Iodoisoquinoline is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. 5-Iodoisoquinoline is selective against other NAD+-processing enzymes, receptors, and transporters. 5-Iodoisoquinoline prevents neurofilament light chain (NfL) release from severed axons in a dose-dependent manner, with an IC50 of ~2 μM.
| Molecular Weight | 255.06 |
| Formula | C9H6IN |
| CAS Number | 58142-99-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 26 mg/mL |
| Storage | 4°C, protect from light |
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