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TLR Toll-like Receptor

Cat.No.  Name Information
M11408 Hydroxychloroquine Hydroxychloroquine is a synthetic antimalarial agent that also inhibits Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine effectively inhibited SARS-COV-2 infection.
M9063 TLR2-IN-C29 C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocked HTLR2/1 and HTLR2/6 with IC50 values of 19.7 and 37.6 μM, respectively.
M4838 TAK-242 (Resatorvid) Resatorvid (TAK-242) is a selective TLR4 signaling inhibitor. Resatorvid inhibited the production of NO, TNF-α and IL-6 with IC50 values of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid down-regulates the expression of MyD88 and TRIF signaling molecules downstream of TLR4. Resatorvid inhibits autophagy and plays a key role in a variety of inflammatory diseases.
M21418 CL097 CL097 is a potent TLR7 and TLR8 agonist that induces pro-inflammatory cytokines in macrophages.CL097 induces NADPH oxidase initiating activity leading to increased fMLF-stimulated ROS production.
M20588 MD2-IN-1 MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD value of 189 μM.
M19443 Robinin Robinin inhibits upregulated expression of TLR2 and TLR4. Robinin ameliorates oxidized low density lipoprotein (Ox-LDL) induced inflammatory insult through TLR4/NF-κB pathway.
M14130 Pam3CSK4 TFA Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2.
M11434 Enpatoran Enpatoran (M5049) is a potentially "first-in-class" orally active Toll-like receptor (TLR) 7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells.
M11423 RS 09 RS09 is a LPS peptide mimicry, which is a new class of TLR4 agonist adjuvant. RS09 can increase antibody production in a vaccine environment.
M11411 1V209 1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist with antitumor effects. 1V209 can be conjugated with various polysaccharides to improve their water solubility, enhance efficacy and maintain low toxicity.
M11407 FSL-1 TFA Fsl-1 TFA is a bacteria-derived toll-like receptor 2/6 (TLR2/6) agonist that enhances resistance to HSV-2 infection. Fsl-1 TFA induces mMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways.
M11308 E6446 E6446 is an inhibitor of Toll-like receptor (TLR) 7 and 9 signaling in a variety of human and mouse cell types and inhibits DNA-TLR9 interactions in vitro.
M11026 CU-T12-9 Cu-t12-9 is a specific TLR1/2 agonist with EC50 of 52.9 nM. Cu-t12-9 activates both the innate and adaptive immune systems.
M10918 TLR7/8 agonist 1 dihydrochloride TLR7/8 agonist 1 dihydrochloride is a dual agonist of toll-like receptor TLR7/TLR8.
M10892 Telratolimod Telratolimod (MEDI9197) is a potent TLR7/8 agonist with antitumor activity.
M10813 DSR-6434 DSR-6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist for both humans and mice with TLR7 EC50 7.2 nM and 4.6 nM, respectively. DSR-6434 has a strong antitumor effect.
M10810 CU-115 CU-115 is a potent TLR8 antagonist (IC50=1.04 µM), and shows selective for TLR8 over TLR7 (IC50=>50 µM). CU-115 decreases TNF-α and IL-1β production activated by R-848 in THP-1 cells.
M10713 Selgantolimod Selgantolimod (GS-9688) is an orally active, potent and selective Toll-like receptor 8 (TLR8) agonist for the study of hepatitis B virus (HBV) and HIV infection.
M10704 SM-276001 SM-276001 is a potent and selective TLR7 agonist that induces an antitumor immune response. SM-276001 is an orally active interferon (IFN) inducer.
M10703 PF-4878691 PF-4878691 (3M-852A) is a highly potent, orally active, selective Toll-like receptor 7 (TLR7) agonist that separates its antiviral activity from its inflammatory activity.

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