Inhibitors
Cat.No. | Name | Information |
---|---|---|
M2227 | Imiquimod | Imiquimod (R837), an imidazoquinoline amine analog to guanosine, is a selective toll like receptor 7 (TLR7) agonist. with potent indirect antiviral activity. |
M4838 | TAK-242 (Resatorvid) | Resatorvid (TAK-242) is a selective TLR4 signaling inhibitor. Resatorvid inhibited the production of NO, TNF-α and IL-6 with IC50 values of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid down-regulates the expression of MyD88 and TRIF signaling molecules downstream of TLR4. Resatorvid inhibits autophagy and plays a key role in a variety of inflammatory diseases. |
M14130 | Pam3CSK4 TFA | Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2. |
M14129 | MMG-11 quarterhydrate | MMG-11 quarterhydrate is a potent and selective human TLR2 antagonist with low cytotoxicity. |
M14128 | Imiquimod hydrochloride | Imiquimod hydrochloride (R 837 hydrochloride), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. |
M14127 | FSL-1 TFA | FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection. |
M11461 | Enpatoran hydrochloride | Enpatoran (M5049) Hydrochloride is a potent and orally active inhibitor of TLR7/8, with IC50s of 11.1 nM and 24.1 nM in HEK293 cells. |
M11434 | Enpatoran | Enpatoran (M5049) is a potent and orally active tlR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. |
M11423 | RS 09 | RS09 is a LPS peptide mimicry, which is a new class of TLR4 agonist adjuvant. RS09 can increase antibody production in a vaccine environment. |
M11411 | 1V209 | 1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist with antitumor effects. 1V209 can be conjugated with various polysaccharides to improve their water solubility, enhance efficacy and maintain low toxicity. |
M11407 | FSL-1 TFA | Fsl-1 TFA is a bacteria-derived toll-like receptor 2/6 (TLR2/6) agonist that enhances resistance to HSV-2 infection. Fsl-1 TFA induces mMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways. |
M11308 | E6446 | E6446 is an inhibitor of Toll-like receptor (TLR) 7 and 9 signaling in a variety of human and mouse cell types and inhibits DNA-TLR9 interactions in vitro. |
M11026 | CU-T12-9 | Cu-t12-9 is a specific TLR1/2 agonist with EC50 of 52.9 nM. Cu-t12-9 activates both the innate and adaptive immune systems. |
M10918 | TLR7/8 agonist 1 dihydrochloride | TLR7/8 agonist 1 dihydrochloride is a dual agonist of toll-like receptor TLR7/TLR8. |
M10846 | LHC-165 | LHC-165 is an agonist of Toll-like receptor 7 (TLR7). There is potential to study solid tumors. |
M10813 | DSR-6434 | DSR-6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist for both humans and mice with TLR7 EC50 7.2 nM and 4.6 nM, respectively. DSR-6434 has a strong antitumor effect. |
M10810 | CU-115 | CU-115 is a powerful TLR8 antagonist (IC50=1.04 µM), AND SHOWS A HIGHER SELECTIVITY FOR TLR8 THAN TLR7 (IC50=>50 µM)。 CU-115 reduces the production of TNF-α and IL-1β in THP-1 cells activated by R-848. |
M10790 | AZD8848 | AZD8848 is a selective TLR7 precursor drug agonist for the study of asthma and allergic rhinitis. |
M10703 | PF-4878691 | PF-4878691 (3M-852A) is a highly potent, orally active, selective Toll-like receptor 7 (TLR7) agonist that separates its antiviral activity from its inflammatory activity. |
M10331 | CRX-527 | CRX-527 is a highly specific and potent TLR4 agonist, which displays significantly less toxicity when compared to LPS. |
M10223 | Okanin | Okanin attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways, it is the effective constituent of the flower tea Coreopsis tinctoria. |
M9904 | ODN 1826 | ODN 1826 is a class B CpG ODN specific for murine TLR9. |
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