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Imiquimod hydrochloride

Cat. No. M14128
Imiquimod hydrochloride Structure

R 837 hydrochloride

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Biological Activity

Imiquimod hydrochloride (R 837 hydrochloride), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod hydrochloride exhibits antiviral and antitumor effects in vivo. Imiquimod hydrochloride can be used for the research of external genital, perianal warts, cancer and COVID-19.

Chemical Information
Molecular Weight 276.76
CAS Number 99011-78-6
Solubility (25°C) DMSO 8 mg/mL (ultrasonic and warming and heat to 50°C)
Water 4.8 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Iori Okura, et al. Fingolimod ameliorates imiquimod-induced psoriasiform dermatitis by sequestrating interleukin-17-producing ?d T cells in secondary lymph nodes

[2] Kent Sakai, et al. Mouse model of imiquimod-induced psoriatic itch

[3] M Bayes, et al. Gateways to Clinical Trials. June 2002

[4] M Bayes, et al. Gateways to clinical trials

[5] M Bayes, et al. Gateways to Clinical Trials

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