About 16 results found for searched term "TLR" (0.223 seconds)
Cat.No. | Name | Target |
---|---|---|
M5105 | MD2-TLR4-IN-1 | TLR |
MD2-TLR4-IN-1 is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. | ||
M6246 | TLR7-agonist-1 | TLR |
TLR7-agonist-1 is a potent and selective Toll-like Receptor 7 (TLR7) agonist with a LEC of 0.4 μM. | ||
M9063 | TLR2-IN-C29 | TLR |
C29 | ||
C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocked HTLR2/1 and HTLR2/6 with IC50 values of 19.7 and 37.6 μM, respectively. | ||
M9651 | TLR4-IN-C34 | TLR |
C34 | ||
C34 is a TLR4 inhibitor, which inhibited TLR4 in enterocytes and macrophages in vitro, and reduced systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. | ||
M10918 | TLR7/8 agonist 1 dihydrochloride | TLR |
TLR7/8 agonist 1 dihydrochloride is a dual agonist of toll-like receptor TLR7/TLR8. | ||
M11411 | 1V209 | TLR |
TLR7 agonist T7 | ||
1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist with antitumor effects. 1V209 can be conjugated with various polysaccharides to improve their water solubility, enhance efficacy and maintain low toxicity. | ||
M14096 | TLR1 | Others |
TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses. | ||
M27994 | TLR7 agonist 3 | TLR |
TLR7 agonist 3 (Compound 2) is a potent agonist of toll-like receptor 7 (TLR7). TLR7 has an important role in immune activation processes and represents an emerging agent discovery target for the development of immunomodulators. | ||
M28075 | TLR7/8 agonist 1 | TLR |
TLR7/8 agonist 1 is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline. | ||
M41562 | TLR7 agonist 13 | Nucleoside Antimetabolite/Analog |
TLR7 agonist 13 is a guanosine analog. | ||
M42063 | TLR7/8 agonist 8 | TLR |
TLR7/8 agonist 8 is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC50s of 27 and 12 nM for hTLR7 and hTLR8, respectively. | ||
M42071 | TLR7/8/9 antagonist 2 | TLR |
TLR7/8/9 antagonist 2 is an orally active TLR7/8/9 antagonist. | ||
M42072 | TLR8 agonist 6 | TLR |
TLR8 agonist 6 is a TLR8 agonist, with an EC50 of 0.052 μM. | ||
M42073 | TLR7 agonist 9 | TLR |
TLR7 agonist 9 is an aonist of TLR7. | ||
M43177 | C12-TLRa | Others |
C12-TLRa is an adjuvant lipidoid. | ||
M53290 | N-myristoyl-RKRTLRRL | PKC |
N-myristoyl-RKRTLRRL inhibits binding of PKC substrates. |
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