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TLR2-IN-C29

Cat. No. M9063
TLR2-IN-C29 Structure
Synonym:

C29

Size Price Availability Quantity
1mg USD 60  USD60 In stock
5mg USD 180  USD180 In stock
10mg USD 270  USD270 In stock
25mg USD 485  USD485 In stock
50mg USD 720  USD720 In stock
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Quality Control & Documentation
Biological Activity

C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocked HTLR2/1 and HTLR2/6 with IC50 values of 19.7 and 37.6 μM, respectively.

Product Citations
Chemical Information
Molecular Weight 285.29
Formula C16H15NO4
CAS Number 363600-92-4
Solubility (25°C) DMSO: ≥ 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mistry P, et al. Proc Natl Acad Sci U S A. Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain.

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Keywords: TLR2-IN-C29, C29 supplier, TLR, inhibitors, activators


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