Free shipping on all orders over $ 500

Atractylenolide I

Cat. No. M4288

All AbMole products are for research use only, cannot be used for human consumption.

Atractylenolide I Structure
Size Price Availability Quantity
5mg USD 86  USD86 In stock
10mg USD 140  USD140 In stock
20mg USD 240  USD240 In stock
50mg USD 460  USD460 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Atractylenolide I is a sesquiterpene obtained from the roots of Atractylenolide. Atractylenolide I has neuroprotective, anti-allergic, anti-inflammatory and anticancer activities. Atractylenolide I is an antagonist of TLR4 and can also reduce the phosphorylation of JAK2 and STAT3 in A375 cells.

Chemical Information
Molecular Weight 230.3
Formula C15H18O2
CAS Number 73069-13-3
Solubility (25°C) DMSO
methanol
Storage 2-8°C, dry, sealed, protect from light
References

[1] Penglin Liu, et al. Atractylenolide I inhibits antibiotic-induced dysbiosis of the intestinal microbiome

[2] Yao Qin, et al. Atractylenolide I Inhibits NLRP3 Inflammasome Activation in Colitis-Associated Colorectal Cancer via Suppressing Drp1-Mediated Mitochondrial Fission

[3] Hanchen Xu, et al. Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation

[4] Caiqin Sun, et al. Atractylenolide I alleviates ischemia/reperfusion injury by preserving mitochondrial function and inhibiting caspase-3 activity

[5] Zi-Xin Mai, et al. Atractylenolide I Can Induce Apoptosis of U266 Cells and Enhance Bortezomib Effect

Related TLR Products
Pepinh-TRIF TFA

Pepinh-TRIF TFA blocks TIR-domain-containing adapter-inducing interferon-β (TRIF) signaling by interfering with TLR-TRIF interaction.

CAY10614

CAY10614 is a potent TLR4 antagonist. CAY10614 inhibits the lipid A-induced activation of TLR4, with an IC50 of 1.675 μM.

TLR4-IN-C34-C2-COOH

TLR4-IN-C34-C2-COO is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.

BNT411 

BNT411 is a selective TLR7 agonist that can induce the release of IFNa both in vivo and in vitro.

Rabeximod

Rabeximod (ROB-803), an anti-rheumatic compound, impairs the differentiation and function of human pro-inflammatory dendritic cells and macrophages via downregulating TLR2 and TLR4 stimulation.

  Catalog
Abmole Inhibitor Catalog




Keywords: Atractylenolide I supplier, TLR, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.