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1V209

Cat. No. M11411
1V209 Structure
Synonym:

TLR7 agonist T7

Size Price Availability Quantity
5mg USD 100  USD100 In stock
10mg USD 160  USD160 In stock
25mg USD 330  USD330 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist with antitumor effects. 1V209 can be conjugated with various polysaccharides to improve their water solubility, enhance efficacy and maintain low toxicity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 359.34
Formula C16H17N5O5
CAS Number 1062444-54-5
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
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Keywords: 1V209, TLR7 agonist T7 supplier, TLR, inhibitors

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