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Zymosan A from Saccharomyces cerevisiae

Cat. No. M21562
Zymosan A from Saccharomyces cerevisiae Structure
Size Price Availability Quantity
50mg USD 60  USD60 In stock
100mg USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

Zymosan A can increase the level of cyclin D2, suggesting the role of cyclin D2 in macrophage activation and proliferation. After injection of galactosamine, it aggravated acute liver injury, suggesting that some non-parenchymal cells besides Kupfer's cells were involved in fermentase action.

Chemical Information
Molecular Weight 211.01
Formula C2H4BrNaO3S
CAS Number 58856-93-2
Solubility (25°C) Insoluble in Water
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Priyanka Arya, et al. Iran J Basic Med Sci. Hidden attributes of zymosan in the pathogenesis of inflammatory diseases: A tale of the fungal agent

[2] Wataru Ariyoshi, et al. Molecules. Biological Effects of β-Glucans on Osteoclastogenesis

[3] Yoshiyuki Miyazaki, et al. Biochem Biophys Res Commun. The cooperative induction of macrophage activation by fucoidan derived from Cladosiphon okamuranus and β-glucan derived from Saccharomyces cerevisiae

[4] Hiroyuki Tada, et al. Microbiol Immunol. Saccharomyces cerevisiae- and Candida albicans-derived mannan induced production of tumor necrosis factor alpha by human monocytes in a CD14- and Toll-like receptor 4-dependent manner

[5] E V Mikhalchik, et al. Biochemistry (Mosc). Carbohydrate-carbohydrate interaction: zymosan and beta-glucan from Saccharomyces cerevisiae bind mannosylated glycoconjugates

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