| Cat.No. | Name | Information |
|---|---|---|
| M4838 | TAK-242 (Resatorvid) | Resatorvid (TAK-242) is a selective TLR4 signaling inhibitor. Resatorvid inhibited the production of NO, TNF-α and IL-6 with IC50 values of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid down-regulates the expression of MyD88 and TRIF signaling molecules downstream of TLR4. Resatorvid inhibits autophagy and plays a key role in a variety of inflammatory diseases. |
| M11408 | Hydroxychloroquine | Hydroxychloroquine is a synthetic antimalarial agent that also inhibits Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine effectively inhibited SARS-COV-2 infection. |
| M9063 | TLR2-IN-C29 | C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocked HTLR2/1 and HTLR2/6 with IC50 values of 19.7 and 37.6 μM, respectively. |
| M42066 | Polyinosinic acid | Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) agonist. |
| M5062 | Polyinosinic:polycytidylic acid | Polyinosinic:polycytidylic acid (poly I:C) is a synthetic polyinosinic-polycytidylic acid double-stranded RNA. Polyinosinic-polycytidylic acid (Poly (I:C)) is an agonist of toll-like receptor (TLR)-3. Polyinosinic-polycytidylic acid has protective effects against cerebral ischemia/reperfusion (I/R) injury and can be used as vaccine adjuvant to enhance innate and adaptive immune responses. |
| M2728 | Vesatolimod (GS-9620) | Vesatolimod (GS-9620) is an effective, selective, oral toll-like receptor 7 (TLR7) agonist with an EC50 value of 291 nM. |
| M21562 | Zymosan A (from Saccharomyces cerevisiae) | Zymosan A can increase the level of cyclin D2, suggesting the role of cyclin D2 in macrophage activation and proliferation. After injection of galactosamine, it aggravated acute liver injury, suggesting that some non-parenchymal cells besides Kupfer's cells were involved in fermentase action. |
| M21418 | CL097 | CL097 is a potent TLR7 and TLR8 agonist that induces pro-inflammatory cytokines in macrophages.CL097 induces NADPH oxidase initiating activity leading to increased fMLF-stimulated ROS production. |
| M20588 | MD2-IN-1 | MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD value of 189 μM. |
| M19443 | Robinin | Robinin inhibits upregulated expression of TLR2 and TLR4. Robinin ameliorates oxidized low density lipoprotein (Ox-LDL) induced inflammatory insult through TLR4/NF-κB pathway. |
| M16160 | Stepharine | Stepharine is an natural alkaloid which directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects. |
| M14130 | Pam3CSK4 TFA | Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2. |
| M14128 | Imiquimod hydrochloride | Imiquimod hydrochloride (R 837 hydrochloride), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. |
| M11434 | Enpatoran | Enpatoran (M5049) is a potentially "first-in-class" orally active Toll-like receptor (TLR) 7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells. |
| M11423 | RS 09 | RS09 is a LPS peptide mimicry, which is a new class of TLR4 agonist adjuvant. RS09 can increase antibody production in a vaccine environment. |
| M11411 | 1V209 | 1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist with antitumor effects. 1V209 can be conjugated with various polysaccharides to improve their water solubility, enhance efficacy and maintain low toxicity. |
| M11407 | FSL-1 TFA | Fsl-1 TFA is a bacteria-derived toll-like receptor 2/6 (TLR2/6) agonist that enhances resistance to HSV-2 infection. Fsl-1 TFA induces mMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways. |
| M11308 | E6446 | E6446 is an inhibitor of Toll-like receptor (TLR) 7 and 9 signaling in a variety of human and mouse cell types and inhibits DNA-TLR9 interactions in vitro. E6446 is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. |
| M11026 | CU-T12-9 | Cu-t12-9 is a specific TLR1/2 agonist with EC50 of 52.9 nM. Cu-t12-9 activates both the innate and adaptive immune systems. |
| M10918 | TLR7/8 agonist 1 dihydrochloride | TLR7/8 agonist 1 dihydrochloride is a dual agonist of toll-like receptor TLR7/TLR8. |
| M10892 | Telratolimod | Telratolimod (MEDI9197) is a potent TLR7/8 agonist with antitumor activity. |
| M10813 | DSR-6434 | DSR-6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist for both humans and mice with TLR7 EC50 7.2 nM and 4.6 nM, respectively. DSR-6434 has a strong antitumor effect. |
| M10810 | CU-115 | CU-115 is a potent TLR8 antagonist (IC50=1.04 µM), and shows selective for TLR8 over TLR7 (IC50=>50 µM). CU-115 decreases TNF-α and IL-1β production activated by R-848 in THP-1 cells. |
| M10784 | AT791 | AT791 is a potent oral bioavailable inhibitor of TLR7 and TLR9. AT791 inhibits TLR7 and TLR9 signaling for a variety of human and mouse cell types and inhibits DNA-TLR9 interactions in vitro. |
| M10713 | Selgantolimod | Selgantolimod (GS-9688) is an orally active, potent and selective Toll-like receptor 8 (TLR8) agonist for the study of hepatitis B virus (HBV) and HIV infection. |
| M10704 | SM-276001 | SM-276001 is a potent and selective TLR7 agonist that induces an antitumor immune response. SM-276001 is an orally active interferon (IFN) inducer. |
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