| Cat.No. | Name | Information |
|---|---|---|
| M4838 | TAK-242 (Resatorvid) | Resatorvid (TAK-242) is a selective TLR4 signaling inhibitor. Resatorvid inhibited the production of NO, TNF-α and IL-6 with IC50 values of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid down-regulates the expression of MyD88 and TRIF signaling molecules downstream of TLR4. Resatorvid inhibits autophagy and plays a key role in a variety of inflammatory diseases. |
| M11408 | Hydroxychloroquine | Hydroxychloroquine is a synthetic antimalarial agent that also inhibits Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine effectively inhibited SARS-COV-2 infection. |
| M9063 | TLR2-IN-C29 | C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocked HTLR2/1 and HTLR2/6 with IC50 values of 19.7 and 37.6 μM, respectively. |
| M42066 | Polyinosinic acid | Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) agonist. |
| M5062 | Polyinosinic:polycytidylic acid | Polyinosinic:polycytidylic acid (poly I:C) is a synthetic polyinosinic-polycytidylic acid double-stranded RNA. Polyinosinic-polycytidylic acid (Poly (I:C)) is an agonist of toll-like receptor (TLR)-3. Polyinosinic-polycytidylic acid has protective effects against cerebral ischemia/reperfusion (I/R) injury and can be used as vaccine adjuvant to enhance innate and adaptive immune responses. |
| M11026 | CU-T12-9 | Cu-t12-9 is a specific TLR1/2 agonist with EC50 of 52.9 nM. Cu-t12-9 activates both the innate and adaptive immune systems. |
| M10918 | TLR7/8 agonist 1 dihydrochloride | TLR7/8 agonist 1 dihydrochloride is a dual agonist of toll-like receptor TLR7/TLR8. |
| M10892 | Telratolimod | Telratolimod (MEDI9197) is a potent TLR7/8 agonist with antitumor activity. |
| M10813 | DSR-6434 | DSR-6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist for both humans and mice with TLR7 EC50 7.2 nM and 4.6 nM, respectively. DSR-6434 has a strong antitumor effect. |
| M10810 | CU-115 | CU-115 is a potent TLR8 antagonist (IC50=1.04 µM), and shows selective for TLR8 over TLR7 (IC50=>50 µM). CU-115 decreases TNF-α and IL-1β production activated by R-848 in THP-1 cells. |
| M10713 | Selgantolimod | Selgantolimod (GS-9688) is an orally active, potent and selective Toll-like receptor 8 (TLR8) agonist for the study of hepatitis B virus (HBV) and HIV infection. |
| M10704 | SM-276001 | SM-276001 is a potent and selective TLR7 agonist that induces an antitumor immune response. SM-276001 is an orally active interferon (IFN) inducer. |
| M10703 | PF-4878691 | PF-4878691 (3M-852A) is a highly potent, orally active, selective Toll-like receptor 7 (TLR7) agonist that separates its antiviral activity from its inflammatory activity. |
| M10331 | CRX-527 | CRX-527 is a highly specific and potent TLR4 agonist, which displays significantly less toxicity when compared to LPS. |
| M10223 | Okanin | Okanin attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways, it is the effective constituent of the flower tea Coreopsis tinctoria. |
| M9904 | ODN 1826 | ODN 1826 is a class B CpG ODN and an agonist of TLR9, which promotes apoptosis and has antitumor activity. In addition, ODN 1826 induces NO and iNOS production in a mouse model. |
| M9746 | CU-CPT-8m | CU-CPT8m is an antagonist of toll-like receptor 8 (TLR8) with Kd of 220 nM and IC50 of 67 nM in assay. |
| M9742 | CU-CPT-9a | CU-CPT-9a is a potent TLR8 antagonist with IC50 of 0.5 nM, which that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells. |
| M9741 | CU-CPT9b | CU-CPT9b is a potent and selective TLR8 inhibitor, with an IC50 of 0.7 nM. |
| M9692 | IAXO-102 | Iaxo-102 is an antagonist of TLR4 and inhibits the TLR4 signaling pathway. Iaxo-102 inhibits phosphorylation of MAPK and P65 NF-KB and expression of TLR4 and TLR4-dependent inflammatory proteins. Iaxo-102 inhibits the development of experimental abdominal aortic aneurysms. |
| M9651 | TLR4-IN-C34 | TLR4-IN-C34 is a TLR4 inhibitor, which inhibited TLR4 in enterocytes and macrophages in vitro, and reduced systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. |
| M9427 | CU-CPT17e | CU-CPT17e is a potent multi-Toll-like receptor (TLR) agonist, which activates TLR3, TLR8 and TLR9. |
| M9289 | E6446 dihydrochloride | E6446 dihydrochloride is a potent and orally acitve antagonist of TLR7 and TLR9. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. |
| M8657 | Sparstolonin B | Sparstolonin B (SsnB), an isocoumarin isolated from Sparganium stoloniferum and Scirpus yagara, is a potent TLR2 and TLR4 antagonist that exhibits anti-inflammatory and anti-viral (anti-HIV) properties. |
| M8408 | CU-CPT22 | CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 shows dose-dependent inhibitory effects blocking Pam3CSK4-induced TLR1/2 activation with an IC50 of 0.58 ± 0.09 µM. |
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