| Cat.No. | Name | Information |
|---|---|---|
| M4838 | TAK-242 (Resatorvid) | Resatorvid (TAK-242) is a selective TLR4 signaling inhibitor. Resatorvid inhibited the production of NO, TNF-α and IL-6 with IC50 values of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid down-regulates the expression of MyD88 and TRIF signaling molecules downstream of TLR4. Resatorvid inhibits autophagy and plays a key role in a variety of inflammatory diseases. |
| M11408 | Hydroxychloroquine | Hydroxychloroquine is a synthetic antimalarial agent that also inhibits Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine effectively inhibited SARS-COV-2 infection. |
| M9063 | TLR2-IN-C29 | C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocked HTLR2/1 and HTLR2/6 with IC50 values of 19.7 and 37.6 μM, respectively. |
| M42066 | Polyinosinic acid | Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) agonist. |
| M5062 | Polyinosinic:polycytidylic acid | Polyinosinic:polycytidylic acid (poly I:C) is a synthetic polyinosinic-polycytidylic acid double-stranded RNA. Polyinosinic-polycytidylic acid (Poly (I:C)) is an agonist of toll-like receptor (TLR)-3. Polyinosinic-polycytidylic acid has protective effects against cerebral ischemia/reperfusion (I/R) injury and can be used as vaccine adjuvant to enhance innate and adaptive immune responses. |
| M54417 | PSMα3 | PSMα3 is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies. |
| M52830 | Pam2CSK4 | Pam2CSK4, a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. |
| M49647 | MAPK-IN-1 | MAPK-IN-1 is a MAPK signaling pathway inhibitor. |
| M45111 | Cobitolimod | Cobitolimod is a first-of-its-kind (first-in-class), synthetic oligodeoxynucleotide (ODN) containing unmethylated CpG motifs that activates TLR9 in specific cells, including intestinal T and B lymphocytes as well as antigen-presenting cells (APCs), and can be used in studies related to inflammatory bowel disease (IBD). |
| M43824 | Agatolimod | Agatolimod is a class B ODN (Oligodeoxynucleotide) and also a TLR9 agonist that stimulates HD11 cells to produce NO2 and IL-6, which can be used in breast cancer related studies. Sequence: 5'-tcgtcgttttgtcgttttgtcgtt-3'. |
| M43823 | Lefitolimod | Lefitolimod is a DNA-based TLR9 agonist and immunosurveillance reactivator that induces HIV-specific immune responses for cancer and HIV-1 research. |
| M43822 | SD-101 | SD-101 is a TLR9 agonist that can be used in tumor-related studies. |
| M43821 | Vidutolimod | Vidutolimod is a CpG-A oligodeoxynucleotide. Vidutolimod is a Toll-like receptor 9 (TLR9) agonist, which activates plasmacytoid dendritic cells (pDCs) and triggers interferon alpha (IFNα) release, leading to a cascade of anti-tumor immune effects. |
| M42073 | TLR7 agonist 9 | TLR7 agonist 9 is an aonist of TLR7. |
| M42072 | TLR8 agonist 6 | TLR8 agonist 6 is a TLR8 agonist, with an EC50 of 0.052 μM. |
| M42071 | TLR7/8/9 antagonist 2 | TLR7/8/9 antagonist 2 is an orally active TLR7/8/9 antagonist. |
| M42070 | Guretolimod hydrochloride | Guretolimod hydrochloride is a Toll-like receptor 7 (TLR7) agonist. |
| M42069 | RDR 02308 | RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase. |
| M42068 | M62812 free base | M62812 (free base) is a toll-like receptor 4 (TLR4) signal transduction inhibitor. |
| M42067 | BMS905 | BMS905 is an orally active TLR7 and TLR8 dual inhibitor (IC50s: 0.7 and 3.2 nM respectively). |
| M42065 | TAT-CIRP | TAT-CIRP is a a small peptide, refers to Trans-trans-activating (Tat)-cold-inducible RNA binding protein. |
| M42064 | Tilsotolimod | Tilsotolimod is a synthetic Toll-like receptor 9 (TLR9) agonist that has demonstrated antitumor activity in preclinical models. |
| M42063 | TLR7/8 agonist 8 | TLR7/8 agonist 8 is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC50s of 27 and 12 nM for hTLR7 and hTLR8, respectively. |
| M42062 | Tilsotolimod sodium | Tilsotolimod (sodium) is a synthetic Toll-like receptor 9 (TLR9) agonist that has demonstrated antitumor activity in preclinical models. |
| M40904 | ODN TTAGGG | ODN TTAGGG is an inhibitory oligodeoxynucleotide (ODN) as well as a TLR9, AIM2 and cGAS antagonist with immunosuppressive activity, which inhibits the activation of the AIM2 inflammasome by competing with DNA, as well as the activation of cGAS. It can be used in the study of autoimmune diseases such as lupus erythematosus. Sequence: 5'-T-T-T-A-G-G-G-T-T-T-T-A-G-G-G-T-T-T-A-G-G-G-T-T-T-A-G-G-G-T-T-T-A-G-G-G-3'. |
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