| Cat.No. | Name | Information |
|---|---|---|
| M4838 | TAK-242 (Resatorvid) | Resatorvid (TAK-242) is a selective TLR4 signaling inhibitor. Resatorvid inhibited the production of NO, TNF-α and IL-6 with IC50 values of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid down-regulates the expression of MyD88 and TRIF signaling molecules downstream of TLR4. Resatorvid inhibits autophagy and plays a key role in a variety of inflammatory diseases. |
| M11408 | Hydroxychloroquine | Hydroxychloroquine is a synthetic antimalarial agent that also inhibits Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine effectively inhibited SARS-COV-2 infection. |
| M9063 | TLR2-IN-C29 | C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocked HTLR2/1 and HTLR2/6 with IC50 values of 19.7 and 37.6 μM, respectively. |
| M42066 | Polyinosinic acid | Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) agonist. |
| M5062 | Polyinosinic:polycytidylic acid | Polyinosinic:polycytidylic acid (poly I:C) is a synthetic polyinosinic-polycytidylic acid double-stranded RNA. Polyinosinic-polycytidylic acid (Poly (I:C)) is an agonist of toll-like receptor (TLR)-3. Polyinosinic-polycytidylic acid has protective effects against cerebral ischemia/reperfusion (I/R) injury and can be used as vaccine adjuvant to enhance innate and adaptive immune responses. |
| M2728 | Vesatolimod (GS-9620) | Vesatolimod (GS-9620) is an effective, selective, oral toll-like receptor 7 (TLR7) agonist with an EC50 value of 291 nM. |
| M56406 | TLR7/8-IN-1 | TLR7/8-IN-1 is a crystalline from of a TLR7/TLR8 inhibitor. |
| M56405 | Ruzotolimod | Ruzotolimod is the agonist of TLR7. |
| M54728 | Kdo2-Lipid A ammonium | Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxic activity equivalent to LPS.Kdo2-Lipid A ammonium is highly selective for TLR4 and stimulates the release of TNF and PGE2. |
| M54417 | PSMα3 | PSMα3 is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies. |
| M52830 | Pam2CSK4 | Pam2CSK4, a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. |
| M49647 | MAPK-IN-1 | MAPK-IN-1 is a MAPK signaling pathway inhibitor. MAPK-IN-1 exhibits AChE inhibitory activity with an IC50 of 23.84 μM. MAPK-IN-1 shows anti-neuroinflammatory and neuroprotective activity. |
| M45111 | Cobitolimod | Cobitolimod is a first-of-its-kind (first-in-class), synthetic oligodeoxynucleotide (ODN) containing unmethylated CpG motifs that activates TLR9 in specific cells, including intestinal T and B lymphocytes as well as antigen-presenting cells (APCs), and can be used in studies related to inflammatory bowel disease (IBD). |
| M43824 | Agatolimod | Agatolimod is a class B ODN (Oligodeoxynucleotide) and also a TLR9 agonist that stimulates HD11 cells to produce NO2 and IL-6, which can be used in breast cancer related studies. Sequence: 5'-tcgtcgttttgtcgttttgtcgtt-3'. |
| M43823 | Lefitolimod | Lefitolimod is a DNA-based TLR9 agonist and immunosurveillance reactivator that induces HIV-specific immune responses for cancer and HIV-1 research. |
| M43822 | SD-101 | SD-101 is a TLR9 agonist that can be used in tumor-related studies. |
| M43821 | Vidutolimod | Vidutolimod is a CpG-A oligodeoxynucleotide. Vidutolimod is a Toll-like receptor 9 (TLR9) agonist, which activates plasmacytoid dendritic cells (pDCs) and triggers interferon alpha (IFNα) release, leading to a cascade of anti-tumor immune effects. |
| M42073 | TLR7 agonist 9 | TLR7 agonist 9 is an aonist of TLR7. |
| M42072 | TLR8 agonist 6 | TLR8 agonist 6 is a TLR8 agonist, with an EC50 of 0.052 μM. |
| M42071 | TLR7/8/9 antagonist 2 | TLR7/8/9 antagonist 2 is an orally active TLR7/8/9 antagonist. |
| M42070 | Guretolimod hydrochloride | Guretolimod hydrochloride is a Toll-like receptor 7 (TLR7) agonist. |
| M42069 | RDR 02308 | RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase. |
| M42068 | M62812 free base | M62812 (free base) is a toll-like receptor 4 (TLR4) signal transduction inhibitor. |
| M42067 | BMS905 | BMS905 is an orally active TLR7 and TLR8 dual inhibitor (IC50s: 0.7 and 3.2 nM respectively). |
| M42065 | TAT-CIRP | TAT-CIRP is a a small peptide, refers to Trans-trans-activating (Tat)-cold-inducible RNA binding protein. |
| M42064 | Tilsotolimod | Tilsotolimod is a synthetic Toll-like receptor 9 (TLR9) agonist that has demonstrated antitumor activity in preclinical models. |
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