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Cobitolimod

Cat. No. M45111

All AbMole products are for research use only, cannot be used for human consumption.

Cobitolimod Structure

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Quality Control & Documentation
Biological Activity

Cobitolimod is a first-of-its-kind (first-in-class), synthetic oligodeoxynucleotide (ODN) containing unmethylated CpG motifs that activates TLR9 in specific cells, including intestinal T and B lymphocytes as well as antigen-presenting cells (APCs), and can be used in studies related to inflammatory bowel disease (IBD).

Chemical Information
Molecular Weight 5925
Formula C185H233N73O106P18S6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Turki AlAmeel, et al. Clin Exp Gastroenterol. Emerging Therapies for Ulcerative Colitis: Updates from Recent Clinical Trials

[2] Laurie B Grossberg, et al. Aliment Pharmacol Ther. Review article: emerging drug therapies in inflammatory bowel disease

[3] Raja Atreya, et al. Lancet Gastroenterol Hepatol. Cobitolimod for moderate-to-severe, left-sided ulcerative colitis (CONDUCT): a phase 2b randomised, double-blind, placebo-controlled, dose-ranging induction trial

[4] Heike Schmitt, et al. J Crohns Colitis. The TLR9 Agonist Cobitolimod Induces IL10-Producing Wound Healing Macrophages and Regulatory T Cells in Ulcerative Colitis

[5] Patrizio Scarozza, et al. Front Pharmacol. Oligonucleotides-A Novel Promising Therapeutic Option for IBD

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Keywords: Cobitolimod supplier, TLR, inhibitors, activators

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