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CU-CPT17e is a potent multi-Toll-like receptor (TLR) agonist, which activates TLR3, TLR8 and TLR9. CU-CPT17e inhibits the proliferation of HeLa cancer cells by triggering apoptosis and arresting the cell cycle at the S phase. CU-CPT17e significantly improves the activity with 13.9±0.9 fold of NF-κB activation and an EC50 value of 4.8±0.7 μM. Treatment with CU-CPT17e for 24 h at different concentrations (10 to 40 μM) results in an elevation of apoptotic cell population ranging from 10% to 17%, which is more effective than poly I:C at 5 μg/mL.
| Molecular Weight | 504.49 |
| Formula | C27H24N2O8 |
| CAS Number | 2109805-75-4 |
| Solubility (25°C) | DMSO ≥ 4 mg/mL (Need ultrasonic and warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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