All AbMole products are for research use only, cannot be used for human consumption.
Enpatoran (M5049) is a potentially "first-in-class" orally active Toll-like receptor (TLR) 7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells. Enpatoran showed no activity against TLR3, TLR4 and TLR9. Enpatoran blocks both molecular synthesis ligand and natural endogenous RNA ligand. Enpatoran showed good pharmacokinetic characteristics in vivo. Enpatoran can be used in the study of congenital and adaptive autoimmune blocking.
| Molecular Weight | 320.31 |
| Formula | C16H15F3N4 |
| CAS Number | 2101938-42-3 |
| Solubility (25°C) | DMSO ≥ 20 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
| Related TLR Products |
|---|
| Pepinh-TRIF TFA
Pepinh-TRIF TFA blocks TIR-domain-containing adapter-inducing interferon-β (TRIF) signaling by interfering with TLR-TRIF interaction. |
| CAY10614
CAY10614 is a potent TLR4 antagonist. CAY10614 inhibits the lipid A-induced activation of TLR4, with an IC50 of 1.675 μM. |
| TLR4-IN-C34-C2-COOH
TLR4-IN-C34-C2-COO is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. |
| BNT411
BNT411 is a selective TLR7 agonist that can induce the release of IFNa both in vivo and in vitro. |
| Rabeximod
Rabeximod (ROB-803), an anti-rheumatic compound, impairs the differentiation and function of human pro-inflammatory dendritic cells and macrophages via downregulating TLR2 and TLR4 stimulation. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
