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Enpatoran

Cat. No. M11434

All AbMole products are for research use only, cannot be used for human consumption.

Enpatoran Structure
Synonym:

M5049

Size Price Availability Quantity
1mg USD 150  USD150 In stock
5mg USD 275  USD275 In stock
10mg USD 440  USD440 In stock
25mg USD 730  USD730 In stock
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Quality Control & Documentation
Biological Activity

Enpatoran (M5049) is a potentially "first-in-class" orally active Toll-like receptor (TLR) 7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells. Enpatoran showed no activity against TLR3, TLR4 and TLR9. Enpatoran blocks both molecular synthesis ligand and natural endogenous RNA ligand. Enpatoran showed good pharmacokinetic characteristics in vivo. Enpatoran can be used in the study of congenital and adaptive autoimmune blocking.

Chemical Information
Molecular Weight 320.31
Formula C16H15F3N4
CAS Number 2101938-42-3
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage -20°C, protect from light, dry, sealed
References

[1] Zulfiqar Ali, et al. Nat Prod Res. Eupatorin 3'- O-glucopyranoside, a trimethoxyflavonoid glucoside from the aerial parts of Salvia mellifera

[2] Marziyeh Shalchi Tousi, et al. J Pharm Anal. Evaluation of apoptotic effects of mPEG-b-PLGA coated iron oxide nanoparticles as a eupatorin carrier on DU-145 and LNCaP human prostate cancer cell lines

[3] Nursyamirah Abd Razak, et al. Integr Cancer Ther. Eupatorin Suppressed Tumor Progression and Enhanced Immunity in a 4T1 Murine Breast Cancer Model

[4] Luya Li, et al. Molecules. Identification of Metabolites of Eupatorin in Vivo and in Vitro Based on UHPLC-Q-TOF-MS/MS

[5] Nursyamirah Abd Razak, et al. Sci Rep. Cytotoxicity of eupatorin in MCF-7 and MDA-MB-231 human breast cancer cells via cell cycle arrest, anti-angiogenesis and induction of apoptosis

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Keywords: Enpatoran, M5049 supplier, TLR, inhibitors, activators

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