About 10 results found for searched term "LIM Kinase" (0.126 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1768 | Rapamycin | mTOR |
| Sirolimus; Rapamune; AY-22989 | ||
| Rapamycin (Sirolimus,Rapamune)is an inhibitor of mTOR.The mammalian target of rapamycin (mTOR) is a kinase responsible for mitogen-induced cell proliferation/survival signaling. | ||
| M5140 | 2-Deoxy-D-glucose | Cell Culture |
| 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose | ||
| 2-Deoxy-D-Glucose (2-DG) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which cannot be further metabolized by phosphoglucose isomerase. | ||
| M6144 | BMS-3 | LIM Kinase |
| BMS-3 is a potent inhibitor of LIMK1.LIM kinase 1 (LIMK1) activity is essential for cell migration and cell cycle progression. | ||
| M6145 | BMS-5 | LIM Kinase |
| LIMKI 3 | ||
| BMS-5 (LIMKi 3) is a potent LIM kinase inhibitor (IC50 values are 7 and 8 nM for LIMK1 and LIMK2 respectively). | ||
| M7016 | Narciclasine | ROCK |
| Lycoricidinol | ||
| Narciclasine is a antiproliferative agent; slows cell cycle progression. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner. | ||
| M8311 | MLR-1023 | Src-bcr-Abl |
| Tolimidone | ||
| MLR-1023 (Tolimidone) is a potent, orally active, allosteric activator of the non-receptor Src-related Lyn kinase that produces lasting glucose lowering, reduces HbA1c levels, and preserves pancreatic β-cells in db/db mice. | ||
| M9332 | Apilimod | Others |
| STA-5326; LAM-002A free base; AIT-101 | ||
| Apilimod is a potent IL-12/IL-23 inhibitor, and it is also a cell permeable small molecule which specifically inhibits PIKfyve with an IC50 of 14 nM in an in vitro kinase assay. | ||
| M20699 | R-10015 | Others |
| R-10015 is a potent, selective inhibitor of LIM domain kinase (LIMK) with IC50 of 38 nM for human LIMK1. R-10015 binds to the ATP-binding pocket and acts as a broad-spectrum antiviral compound for HIV infection. | ||
| M38929 | Curcolonol | LIM Kinase |
| Curcolonol is a furan type sesquiterpene. Curcolonol can be isolated from several medical herbs. Curcolonol has inhibitory activity for LIM kinase 1. Curcolonol can be used for the research of breast cancer. | ||
| M41519 | LIMK-IN-1 | LIM Kinase |
| LIMK-IN-1 is an inhibitor of LIM-Kinase (LIMK), with IC50s of 0.5 nM and 0.9 nM for LIMK1 and LIMK2, respectively. | ||
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