About 19 results found for searched term "TGF-β Receptor" (0.124 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1794 | SB431542 | ALK |
| SB-431542 | ||
| SB-431542 is a potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM). | ||
| M1859 | RepSox (ALK5 Inhibitor II) | ALK |
| RepSox; E-616452; SJN 2511; 616452 | ||
| RepSox (ALK5 Inhibitor II) is a potent and ATP-competitive inhibitor of the TGF-β type I receptor ALK5 (IC50 values are 0.004 and 0.023 μM for ALK5 autophosphorylation and ALK5 binding respectively). | ||
| M2016 | LY364947 | TGF-β Receptor |
| HTS 466284 | ||
| LY364947 is a selective small molecule inhibitor of the TGFβ type I receptor kinase with IC50 of 59 nM. | ||
| M2081 | LY2109761 | TGF-β Receptor |
| LY-2109761 | ||
| LY2109761 is a novel TGF-β receptor type I and type II dual inhibitor, with Ki values of 38 nM and 300 nM, respectively. | ||
| M2108 | SB-525334 | TGF-β Receptor |
| SB-525334 is a potent activin receptor-like kinase (ALK5)/ type I TGFβ-receptor kinase inhibitor with IC50 of 14.3 nM. | ||
| M2550 | SB-505124 | TGF-β Receptor |
| Sb-505124 is a selective inhibitor of TGF-βI receptor (ALK4, ALK5, ALK7) with IC50 values of 129 nM and 47 nM for ALK4 and ALK5, respectively. Sb-505124 also inhibits ALK7, but not ALK1, 2, 3 and 6. | ||
| M2610 | D4476 | Casein Kinase |
| Casein Kinase I Inhibitor | ||
| D4476 is a selective inhibitor of casein kinase 1 (CK1) and TGF-β type-I receptor (ALK5) with IC50 of 0.3 µM and 0.5 µM, respectively. | ||
| M5036 | A 77-01 | TGF-β Receptor |
| A 77-01 is a potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. | ||
| M5037 | A 83-01 | TGF-β Receptor |
| A83-01; A-83-01 | ||
| A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively).*The compound is unstable in solutions, freshly prepared is recommended | ||
| M5246 | EW-7197 | TGF-β Receptor |
| Vactosertib; TEW-7197 | ||
| EW-7197 is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively. | ||
| M9222 | LY3200882 | TGF-β Receptor |
| LY3200882 is a potent, highly selective, ATP-competitive and orally active TGF-β receptor type 1 (ALK5) inhibitor with an IC50 of 38.2 nM. LY3200882 is also used as an immune modulatory agent. | ||
| M9243 | ITD-1 | TGF-β Receptor |
| ITD-1 is a selective TGFβ receptor inhibitor with an IC50 of about 0.4-0.8 μM. | ||
| M14930 | Disitertide diammonium | TGF-beta/Smad |
| P144 diammonium | ||
| Disitertide (P144) diammonium is a polypeptide inhibitor of transforming growth factor TGFβ1, specifically blocking its interaction with the receptor. Disitertide diammonium was also an inhibitor of PI3K and an inducer of apoptosis. | ||
| M55622 | Recombinant Human BMPRIA/ALK-3/CD292 Protein (HEK293, C-His) | Cytokines and Growth Factors |
| Bone Morphogenetic Protein Receptor type IA; Activin receptor-Like Kinase 3; ACVRLK3 | ||
| BMPR1A/ALK-3/CD292 protein is expressed in the epithelium during branching morphogenesis. It is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta (TGF-β) superfamily. BMPR1A/ALK-3 plays an essential role in the formation of embryonic ventral abdominal wall, and abrogation of BMP signaling activity due to gene mutations in its signaling components could be one of the underlying causes of omphalocele at birth. The type IA BMP receptor, ALK-3 was specifically required at mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum, and endocardial cushion. | ||
| M25343 | Sudubrilimab | PD-1/PD-L1 |
| HS636 | ||
| Sudubrilimab (HS636) is an Ig G1-kappa monoclonal antibody against PDL1. Sudubrilimab is fused at the C terminus of the heavy chain to a TGF-β1 receptor Ⅱ ectodomain (TGFBR2-ECD), and which can sequester the PD-1/PD-L1 pathway and TGF-β bioactivity in the immunosuppressive tumor microenvironment. | ||
| M29038 | Isosaponarin | TGF-β Receptor |
| Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin increases collagen synthesis, caused by up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production. | ||
| M29975 | SB-505124 hydrochloride | TGF-β Receptor |
| SB-505124 hydrochloride is a selective inhibitor of TGF-β Receptor type I receptor (ALK4, ALK5, ALK7), with IC50s of 129 nM and 47 nM for ALK4, ALK5, respectively, but it does not inhibit ALK1, 2, 3, or 6. | ||
| M54721 | A 83-01 sodium | TGF-beta/Smad |
| A 83-01 sodium is a potent inhibitor of TGF-β type I receptors ALK5, ALK4, and ALK7, inhibiting ALK5, ALK4, and ALK7-induced transcription with IC50 values of 12 nM, 45 nM, and 7.5 nM, respectively. | ||
| M58453 | Recombinant Human BMP-6 (E.coli, C-His) | Cytokines and Growth Factors |
| Bone Morphogenetic Protein-6 | ||
| Bone Morphogenetic Protein-6 (BMP-6) is an extracellular multifunctional cytokine that is also a member of the TGF-β family. BMP-6 can bind with the TGF-β receptor and triggers SMAD protein signal transduction. It plays a vital role in regulating hepcidin to maintain iron ions in the body. | ||
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