About 20 results found for searched term "Receptor Proteins" (0.131 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3983 | Puerarin | 5-HT Receptor |
| Puerarin is a 5-HT2C receptor antagonist. Puerarin inhibits the expression of LPS-induced iNOS, COX-2 and CRP proteins and also suppresses their mRNAs from RT-PCR experiments in RAW264.7 cells. | ||
| M6215 | TAPI-0 | MMP |
| TAPI-0 is an inhibitor which blocks the maturation of cytokines, soluble cyokine receptors and other proteins that require the action of proteases. | ||
| M6240 | Angiotensin II human | Animal Modeling |
| Angiotensin II; Hypertensin II; Ang II; DRVYIHPF | ||
| Angiotensin II human is converted by Angiotensin I through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE). Angiotensin II is mediated by AT1 and AT2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity. Keep away from light and prepare for use now. | ||
| M8774 | CID 1375606 | Others |
| CID1375606 | ||
| CID 1375606 (N-[4-(Anilinocarbonyl)ph |
||
| M9865 | Recombinant mouse IFN-γ (E. coli) | Cytokines and Growth Factors |
| IFN gamma | ||
| Recombinant mouse IFN-γ (Murine IFN-γ) （E. coli）is an unstable interferon produced by CD4 and CD8 T lymphocytes and activated NK cells. IFN-γ receptors are present in most immune cells, and they respond to IFN-γ signaling by increasing the surface expression of class I γ proteins. ED50 < 0.15 ng/ml, measured by cytotoxicity assay using WEHI-279 cells. | ||
| M13379 | Guggulsterone | Apoptosis |
| Z/E-Guggulsterone | ||
| Guggulsterone is a plant sterol from the gum fat of the Commiphora Wightii tree. Guggulsterone is a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. | ||
| M15008 | Recombinant Human Carboxypeptidase E/CPE (HEK293,C-6His) | Cytokines and Growth Factors |
| Carboxypeptidase H; Enkephalin convertase | ||
| CPE acts as a sorting receptor for targeting regulated secretory proteins which are mostly prohormones and neuropeptides in the trans-Golgi network of the pituitary and in secretory granules into the secretory pathway. | ||
| M21203 | Recombinant Human/Mouse/Rat Irisin (HEK293, C-6His) | Cytokines and Growth Factors |
| Fibronectin type III domain-containing protein 5 | ||
| Fibronectin type III domain-containing protein 5 is the precursor of irisin. Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts. | ||
| M21204 | Recombinant Human/Mouse/Rat Irisin (HEK293, C-Fc) | Cytokines and Growth Factors |
| Fibronectin type III domain-containing protein 5 | ||
| Fibronectin type III domain-containing protein 5 is the precursor of irisin. Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts. | ||
| M21205 | Recombinant Human/Mouse/Rat Irisin (HEK293, N-6His) | Cytokines and Growth Factors |
| Fibronectin type III domain-containing protein 5 | ||
| Fibronectin type III domain-containing protein 5 is the precursor of irisin. Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts. | ||
| M24570 | Dalantercept | TGF-beta/Smad |
| ACE-041 | ||
| Dalantercept (ACE-041) is an activin receptor like kinase 1 (ALK1) inhibitor, a ligand trap for bone morphogenetic proteins (BMP) 9 and BMP 10. Dalantercept reduces tumor angiogenesis and delays tumor growth by binding to BMP 9 and BMP 10. As an anti angiogenic agent, Dalantercept has potential applications in persistent or recurrent ovarian cancer, renal cell carcinoma (RCC), and related malignant tumors. | ||
| M24837 | Tebentafusp | IL Receptor/Related |
| IMCgp100 | ||
| Tebentafusp (IMCgp100) is a bispecific fusion protein to target gp100 peptide-HLA-A*02:01 (a melanoma-associated antigen). Tebentafusp guides T cells to kill gp100-expressing tumor cells via a high affinity T-cell receptor (TCR) binding domain and an anti-CD3 T-cell engaging domain. Tebentafusp leads to inflammatory cytokines and cytolytic proteins production, resulting in the direct lysis of tumour cells. | ||
| M55622 | Recombinant Human BMPRIA/ALK-3/CD292 Protein (HEK293, C-His) | Cytokines and Growth Factors |
| Bone Morphogenetic Protein Receptor type IA; Activin receptor-Like Kinase 3; ACVRLK3 | ||
| BMPR1A/ALK-3/CD292 protein is expressed in the epithelium during branching morphogenesis. It is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta (TGF-β) superfamily. BMPR1A/ALK-3 plays an essential role in the formation of embryonic ventral abdominal wall, and abrogation of BMP signaling activity due to gene mutations in its signaling components could be one of the underlying causes of omphalocele at birth. The type IA BMP receptor, ALK-3 was specifically required at mid-gestation for normal development of the trabeculae, compact myocardium, interventricular septum, and endocardial cushion. | ||
| M29038 | Isosaponarin | TGF-β Receptor |
| Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin increases collagen synthesis, caused by up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production. | ||
| M29582 | β-NF-JQ1 | PROTAC |
| β-NF-JQ1 is a PROTAC that recruits Aryl Hydrocarbon Receptor E3 ligase to target proteins. β-NF-JQ1 is directed against bromodomain-containing (BRD) proteins using β-NF as an AhR ligand, induces the interaction of AhR and BRD proteins, and displays effective anticancer activity that correlated with protein knockdown activity. | ||
| M43891 | Pisum sativum agglutinin | Others |
| PSA | ||
| Pisum sativum agglutinin, a lectin derived from pea, can be utilized for studies related to the characterization of glycoconjugates by taking advantage of its ability to react with cell surface receptors and glycoproteins. | ||
| M55306 | Guanosine 3′,5′-cyclic monophosphate | Others |
| cGMP | ||
| Guanosine 3′,5′-cyclic monophosphate (cGMP) acts as an important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG). | ||
| M55355 | Recombinant Mouse IGF-1 (E.coli, C-6His) | Cytokines and Growth Factors |
| Insulin-like Growth Factor I; LR3-IGF-1; Somatomedin C | ||
| Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally. It plays an important role in muscle regeneration and tumor progression. IGF-I binds IGF-I R, IGF-II R, and the insulin receptor. IGF-I association with IGF binding proteins increases its plasma half-life and modulates its interactions with receptors. | ||
| M55621 | Recombinant Human ACVR2A Protein (HEK293, C-6His) | Cytokines and Growth Factors |
| Activin Receptor Type-2A; ACTR-IIA; ACVR2 | ||
| Activin Receptor Type-2A (ACVR2A) is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. | ||
| M58101 | Recombinant Human EGFR Protein (CHO, C-His) | Cytokines and Growth Factors |
| ERBB; ERBB1; HER1; Epidermal Growth Factor Receptor | ||
| EGFR, also known as ERBB, ERBB1 and HER1, is a type I transmembrane protein belonging to the tyrosine protein kinase family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. EGFR also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. | ||
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