About 10 results found for searched term "Mineralocorticoid Receptor" (0.124 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3028 | Spironolactone | Mineralocorticoid Receptor |
| SC9420; Abbolactone | ||
| Spironolactone (SC9420) is an oral active aldosterone mineralocorticoid receptor antagonist with an IC50 value of 24 nM. Spironolactone is also an androgen receptor antagonist with an IC50 of 77 nM. Spironolactone promotes podocyte autophagy. | ||
| M6558 | Canrenone | Mineralocorticoid Receptor |
| Aldadiene; SC9376; SC14266 | ||
| Canrenone is a mineralocorticoid receptor antagonist. | ||
| M7228 | RU 28318, potassium salt | Others |
| RU 28318, potassium salt is a potent, selective mineralocorticoid receptor antagonist. | ||
| M8138 | RU 26752 | Others |
| RU 26752 is a mineralocorticoid receptor antagonist. | ||
| M9125 | Z-Guggulsterone | Farnesoid X Receptor |
| Z-Guggulsterone is a mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection. | ||
| M10479 | Esaxerenone (CS-3150) | Mineralocorticoid Receptor |
| CS-3150; XL-550 | ||
| Esaxerenone (CS-3150) is a highly potent and selective non-steroidal mineralocorticoid receptor antagonist. | ||
| M14337 | 11beta-Hydroxyprogesterone | Metabolite/Endogenous Metabolite |
| 11β-Hydroxyprogesterone | ||
| 11beta-Hydroxyprogesterone is a potent inhibitors of 11β-Hydroxysteroid dehydrogenase; also activates human mineralocorticoid receptor in COS-7 cells with an ED50 of 10 nM. | ||
| M21053 | Apararenone | Mineralocorticoid Receptor |
| MT-3995 | ||
| Apararenone is an oral nonsteroidal mineralocorticoid receptor (MR) antagonist. | ||
| M29590 | AL-438 | GCR |
| AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity. | ||
| M29988 | Ecdysone | Metabolite/Endogenous Metabolite |
| α-Ecdysone | ||
| Ecdysone (α-Ecdysone), a major steroid hormone in insects and herbs, triggers mineralocorticoid receptor (MR) activation and induces cellular apoptosis. Ecdysone plays essential roles in coordinating developmental transitions and homeostatic sleep regulation through its active metabolite 20-hydroxyecdysone (Crustecdysone; 20E). | ||
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