About 9 results found for searched term "Fusion Proteins" (0.124 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2585 | GNF-5837 | Trk |
| GNF-5837 is a potent pan-Trk inhibitor which display antiproliferative effects in cellular Ba/F3 assays (IC50 values are 7, 9 and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively. | ||
| M5997 | Teprenone | HSP |
| Geranylgeranylacetone | ||
| Teprenone(Geranylgeranylacetone; GGA)is commonly utilized to protect the gastric mucosa in peptic ulcer disease; has been shown to protect the myocardium from ischemia/reperfusion by activating heat shock proteins. | ||
| M9389 | 740 Y-P | PI3K |
| PDGFR 740Y-P; 740YPDGFR | ||
| 740 Y-P is a potent and cell permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone. | ||
| M9397 | MS4078 | ALK |
| MS4078 is a PROTAC degrader of ALK which potently decreases cellular levels of oncogenic active ALK fusion proteins in SU-DHL-1 lymphoma and NCI-H2228 lung cancer cells. | ||
| M13547 | AP20187 | Others |
| B/B Homodimerizer | ||
| AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions. | ||
| M24837 | Tebentafusp | Fusion Proteins |
| IMCgp100 | ||
| Tebentafusp (IMCgp100) is a bispecific fusion protein to target gp100 peptide-HLA-A*02:01 (a melanoma-associated antigen). Tebentafusp guides T cells to kill gp100-expressing tumor cells via a high affinity T-cell receptor (TCR) binding domain and an anti-CD3 T-cell engaging domain. Tebentafusp leads to inflammatory cytokines and cytolytic proteins production, resulting in the direct lysis of tumour cells. | ||
| M25473 | HaloPROTAC3 | Ligand for E3 Ligase |
| VH285-PEG4-C4-Cl | ||
| HaloPROTAC3 is a conjugate of ligands for E3 and 16-atom-length linker, and it is also a highly potent and efficacious degrader of GFP-HaloTag7 fusion proteins with a DC50 of 19 nM. | ||
| M29737 | dTAGV-1 TFA | PROTAC |
| dTAGV-1 TFA is a potent and selective degrader of mutant FKBP12F36V fusion proteins. dTAGV-1 TFA can induce degradation of FKBP12F36V-Nluc in vivo. | ||
| M40644 | PreScission Protease | Enzymes & Coenzymes |
| HRV 3C Protease; HRV3C Protease | ||
| PreScission Protease is a recombinantly expressed 3C protease of human rhinovirus type 14 with a GST tag in Escherichia coli that specifically recognizes the octapeptide sequence Leu-Glu-Val-Leu-Phe-Gln-Gly-Pro or the core pentapeptide sequence Leu-Phe-Gln-Gly-Pro at low temperature (4°C) and cleaves between Gln and Gly amino acid residues. Pro and enzymatically cleaves between Gln and Gly amino acid residues, commonly used to remove Glutathione S-transferase (GST), His, or other tags from fusion proteins. | ||
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