About 14 results found for searched term "Dihydrofolate reductase" (0.124 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3254 | Pyrimethamine | Antifolate |
| Pirimecidan; Pirimetamin; RP 4753 | ||
| Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM. | ||
| M3262 | Methotrexate metabolite | Antifolate |
| DAMPA; NSC 131463 | ||
| Methotrexate metabolite is a dihydrofolate reductase potent inhibitor with an IC50 of 1 nM. | ||
| M7108 | Pemetrexed | Antifolate |
| LY231514 | ||
| Pemetrexed is a thymidylate synthetase inhibitor, also inhibits dihydrofolate reductase, GARFT and AICART. | ||
| M8855 | WR99210 | Others |
| WR99210 is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (DHFR), which is a major malarial drug target. | ||
| M9787 | Aminopterin | Antifolate |
| 4-Aminofolic acid | ||
| Aminopterin is a folic acid derivative used as a rodenticide that has been shown to be teratogenic, and a dihydrofolate reductase inhibitor used to treat rheumatoid arthritis and leukemia. | ||
| M13588 | Methotrexate disodium | Antifolate |
| Amethopterin disodium; CL14377 disodium; WR19039 disodium | ||
| Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. | ||
| M20465 | Diaveridine | Others |
| AI3-23935, CCRIS-3784 | ||
| Diaveridine is coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis. | ||
| M20554 | Proguanil | Anti-infection |
| chlorguanide, chloroguanide | ||
| Proguanil is a prophylactic antimalarial drug. It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. | ||
| M28781 | Trimetrexate trihydrochloride | Dihydrofolate reductase |
| CI-898 trihydrochloride | ||
| Trimetrexate (CI-898) trihydrochloride is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. | ||
| M29261 | Fanotaprim | Antifolate |
| VYR-006 | ||
| Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor with IC50s of 1.57 and 308 nM for tgDHFR (Toxoplasma gondii DHFR) and hDHFR (human DHFR), respectively. Fanotaprim has the potential for the research of toxoplasmosis. | ||
| M29977 | Pemetrexed disodium heptahydrate | Antifolate |
| LY231514 disodium heptahydrate | ||
| Pemetrexed disodium heptahydrate is a novel antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively. | ||
| M30234 | Trimetrexate | Dihydrofolate reductase |
| CI-898 | ||
| Trimetrexate (CI-898) is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate can also inhibit the growth of various cancer cells. Trimetrexate can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer. | ||
| M30658 | Trimetrexate isethionate | Dihydrofolate reductase |
| CI-898 isethionate | ||
| Trimetrexate (CI-898) isethionate is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate isethionate can also inhibit the growth of various cancer cells. Trimetrexate isethionate can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer. | ||
| M30659 | Trimetrexate glucuronate | Antifolate |
| CI-898 glucuronate | ||
| Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential antitumour activity and can also be used to inhibit Pneumocystis carinii pneumonia. | ||
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