| Cat.No. | Name | Information |
|---|---|---|
| M2048 | Sumatriptan succinate | Sumatriptan succinate (GR 43175) is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for the research of migraine headache. |
| M3417 | Clozapine | Clozapine is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis. |
| M2821 | Lorcaserin hydrochloride | Lorcaserin hydrochloride is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM. |
| M5656 | Fluoxetine hydrochloride | Fluoxetine hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. |
| M14577 | Fluoxetine | Fluoxetine (LY-110140 free base) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research. |
| M3659 | Pimavanserin | Pimavanserin is a selective serotonin 5-HT2A inverse agonist. |
| M3374 | Zolmitriptan | Zolmitriptan is a 5-HT1B/1D-angiotensin receptor (5-HT1B/1D-AR) partial agonist with Ki's of 5.01 nM, 0.63 nM, and 63.09 nM for 5-HT1B, 5-HT1D, and 5-HT1F receptors, respectively.Zolmitriptan can be used in studies related to migraine. |
| M3364 | Mirtazapine | Mirtazapine is a potent tetracyclic antidepressant. |
| M3363 | RS-127445 | RS-127445 is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors. |
| M3320 | Quetiapine Fumarate | Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. |
| M3239 | Ketanserin | Ketanserin is specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A. |
| M3223 | LY310762 | LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor. |
| M3211 | Ondansetron | Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic. |
| M3201 | Azasetron dihydrochloride | Azasetron dihydrochloride is the hydrochloride form of Azasetron and is also an orally active 5-HT3 receptor antagonist for studies related to ear disorders such as sudden hearing loss. |
| M3166 | Pindolol | Pindolol is a nonselective beta blocker with partial beta-adrenergic receptor agonist activity. |
| M3164 | Quipazine maleate | Quipazine maleate is a non-selective serotonin receptor agonist. |
| M3160 | Vilazodone | Verazodone (EMD 68843; SB 659746A) is a complex serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently being evaluated in clinical studies for major depression. |
| M3155 | XEN445 | XEN445 is a potent and selective EL inhibitor (IC50=0.237 uM) which shows good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice. |
| M3127 | VUF 10166 | VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower. |
| M3006 | Sertraline hydrochloride | Sertraline hydrochloride is a 5-HT antagonist with Ki of 13 nM. |
| M3004 | Serotonin hydrochloride | Serotonin hydrochloride is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist. |
| M3000 | SB742457 (Intepirdine) | SB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. |
| M2999 | SB271046 | SB271046 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9, exhibits 200-fold greater selectivity over other 5-HT receptor subtypes. |
| M2966 | PRX-08066 Maleic acid | PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat model. |
| M2965 | Prucalopride Succinat | Prucalopride is a selective, high affinity 5-HT4 receptor agonist, inhibiting human 5-HT(4a) and 5-HT(4b) receptor with Ki value of 2.5 nM and 8 nM, respectively. |
| M2852 | Milnacipran hydrochloride | Milnacipran inhibits both norepinephrine transporter (NET) and norepinephrine transporter (SERT) with IC50 of 77 nM and 420 nM, respectively. |
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