| Cat.No. | Name | Information |
|---|---|---|
| M2048 | Sumatriptan succinate | Sumatriptan succinate (GR 43175) is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for the research of migraine headache. |
| M3417 | Clozapine | Clozapine is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis. |
| M2821 | Lorcaserin hydrochloride | Lorcaserin hydrochloride is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM. |
| M5656 | Fluoxetine hydrochloride | Fluoxetine hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. |
| M14577 | Fluoxetine | Fluoxetine (LY-110140 free base) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research. |
| M3659 | Pimavanserin | Pimavanserin is a selective serotonin 5-HT2A inverse agonist, with pIC50 and pKd of 8.73 and 9.3, respectively. |
| M3006 | Sertraline hydrochloride | Sertraline hydrochloride is a 5-HT antagonist with Ki of 13 nM. |
| M4281 | Isocorynoxeine | Isocorynoxeine, an alkaloid related to uncarline, showed a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM. |
| M3997 | Nuciferine | Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM). Nuciferine possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. |
| M3983 | Puerarin | Puerarin is a 5-HT2C receptor antagonist. Puerarin inhibits the expression of LPS-induced iNOS, COX-2 and CRP proteins and also suppresses their mRNAs from RT-PCR experiments in RAW264.7 cells. |
| M3791 | YM 90K hydrochloride | YM 90K hydrochloride is a selective AMPA antagonist with neuro-protective effect. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4. |
| M3782 | Oxiracetam | Oxiracetam could decrease neural injury and increase ability of learning, memory and space cognition in traumatic brain injury rats. |
| M3772 | SB242084 | SB242084 has a high affinity (pKi 9.0) for the cloned human 5-HT2C receptor and 100- and 158-fold selectivity over the closely related cloned human 5-HT2B and 5-HT2A subtypes respectively. |
| M3670 | Metoclopramide hydrochloride | Metoclopramide hydrochloride is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting. |
| M3646 | Cyclobenzaprine hydrochloride | Cyclobenzaprine hydrochloride is a skeletal muscle relaxant and a central nervous system (CNS) depressant. |
| M3583 | Urapidil hydrochloride | Urapidil hydrochloride is an α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. |
| M3529 | BMY 7378 dihydrochloride | BMY 7378 is a multi-targeted inhibitor of α2C-adrenoceptor and α1D-adrenoceptor with pKi of 6.54 and 8.2, respectively, and acts as a mixed agonist and antagonist for 5-HT1A receptor with pKi of 8.3. |
| M3524 | BRL-15572 dihydrochloride | BRL-15572 is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor. |
| M3481 | WAY-100635 Maleate | WAY-100635 maleate is a potent, selective 5-HT1A receptor antagonist with an IC50 value of 0.91 nM, a Ki value of 0.39 nM, and a pIC50 of 8.87, which is more than 100-fold more selective than for use at the other 5-HT receptor subtypes and major neurotransmitter receptors. In addition, WAY-100635 maleate is a potent dopamine D4 receptor agonist. |
| M3479 | Aripiprazole | Aripiprazole is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM. Aripiprazole (OPC-14597) is a potent and high-affinity dopamine D2 receptor partial agonist. |
| M3472 | Naratriptan | Naratriptan is a compound in the triptans family that has been studied for migraine. |
| M3419 | Dapoxetine hydrochloride | Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor. |
| M3414 | Olanzapine | Olanzapine is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist. |
| M3374 | Zolmitriptan | Zolmitriptan is a 5-HT1B/1D-angiotensin receptor (5-HT1B/1D-AR) partial agonist with Ki's of 5.01 nM, 0.63 nM, and 63.09 nM for 5-HT1B, 5-HT1D, and 5-HT1F receptors, respectively.Zolmitriptan can be used in studies related to migraine. |
| M3364 | Mirtazapine | Mirtazapine is a potent tetracyclic antidepressant. |
| M3363 | RS-127445 | RS-127445 is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors. |
| M3320 | Quetiapine Fumarate | Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. |
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