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Xanthotoxol

Cat. No. M4367
Xanthotoxol Structure
Synonym:

8-Hydroxypsoralen

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20mg USD 150  USD150 In stock
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Biological Activity

Xanthotoxol (8-hydroxypsoralen) is a bioactive linear furan coumarin with strong pharmacological activities such as anti-inflammatory, antioxidant, 5-HT antagonist and neuroprotective effects.

Chemical Information
Molecular Weight 202.16
Formula C11H6O4
CAS Number 2009-24-7
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Baimei Shi, et al. Effect of co-administration of Acori Tatarinowii Rhizoma volatile oil on pharmacokinetic fate of xanthotoxol, oxypeucedanin hydrate, and byakangelicin from Angelicae Dahuricae Radix in rat

[2] Guiyuan He, et al. Identification and characterization of human UDP-glucuronosyltransferases responsible for xanthotoxol glucuronidation

[3] Zhongnv Ma, et al. Metabolism and Metabolic Inhibition of Xanthotoxol in Human Liver Microsomes

[4] Wei He, et al. Xanthotoxol exerts neuroprotective effects via suppression of the inflammatory response in a rat model of focal cerebral ischemia

[5] Chuan Xiao, et al. Synthesis of methyl-substituted xanthotoxol to clarify prooxidant effect of methyl on radical-induced oxidation of DNA

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Keywords: Xanthotoxol, 8-Hydroxypsoralen supplier, 5-HT Receptor, inhibitors, activators

 
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