Granisetron hydrochloride (Kytril) is a SR-3 antagonist used as an antiemetic. It reduces the activity of the vagus nerve. In guinea-pig isolated ileum, Granisetron hydrochloride (BRL-43694) antagonised the contractions evoked by relatively high concentrations of 5-HT (pA2 = 8.1 +/- 0.2). Granisetron hydrochloride (BRL-43694) did not affect electrically evoked, cholinergically mediated contractions of rat or human isolated stomach.
| Molecular Weight | 348.87 |
| Formula | C18H24N4O.HCl |
| CAS Number | 107007-99-8 |
| Solubility (25°C) | Water 80 mg/mL DMSO 4 mg/mL |
| Storage | 4°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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