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5-HT Receptor 5-hydroxytryptamine receptor

Cat.No.  Name Information
M14577 Fluoxetine Fluoxetine (LY-110140 free base) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.
M5656 Fluoxetine hydrochloride Fluoxetine hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
M3659 Pimavanserin Pimavanserin is a selective serotonin 5-HT2A inverse agonist, with pIC50 and pKd of 8.73 and 9.3, respectively.
M3417 Clozapine Clozapine is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis.
M2821 Lorcaserin hydrochloride Lorcaserin hydrochloride is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM.
M2048 Sumatriptan succinate Sumatriptan succinate (GR 43175) is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for the research of migraine headache.
M55224 Vabicaserin hydrochloride Vabicaserin hydrochloride is a 5-hydroxytryptamine 2C (5-HT2C) receptor-selective agonist with an EC50 of 8 nM.
M45090 2-Methyl-5-hydroxytryptamine 2-Methyl-5-hydroxytryptamine is a potent, selective 5-HT3 receptor agonist that can be used in depression-related studies.
M40960 Gepirone Gepirone (Gepirone) is a first-in-class, selective, affinity-based, orally active 5-HT1A receptor partial agonist as well as a 5-HT2A receptor antagonist for use in studies related to anxiety, depression, and chronic kidney disease.
M31104 Strictosidinic acid Strictosidinic acid is an orally active glycoside indole monoterpene alkaloid, which inhibits precursor enzymes of 5-HT biosynthesis and reduces the 5-HT levels.
M30583 8-OH-DPAT hydrobromide 8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-OH-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site.
M30283 Cinanserin hydrochloride Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro.
M28078 Aripiprazole Lauroxil  Aripiprazole lauroxil, an N-acyloxymethyl?proagent?of?aripiprazole, is a?Long-acting injectable (LAI)?typical antipsychotic for?schizophrenia. Aripiprazole lauroxil is cleaved by body’s enzyme esterase to N-hydroxymethyl aripiprazole (plus lauric acid) and then to aripiprazole (plus formaldehyde), no toxicity.
M27904 Lumateperone tosylate Lumateperone (ITI-007) tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone tosylate has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia.
M25597 LY03005 hydrochloride LY03005 hydrochloride, the hydrochloride form of LY03005, is also a triple reuptake inhibitor that inhibits the reuptake of serotonin, dopamine, and norepinephrine with IC50 values of 723 nM, 491 nM, and 763 nM, respectively.
M25487 PU02 PU02 (NMMP) is a potent and selective negative allosteric modulator (NAM) of 5-HT3 receptor, displaying IC50 values of ~1 μM at 5-HT(3)Rs and substantially lower activities at other Cys-loop receptors. PU02 inhibits the proliferation of hepatocellular carcinoma (HepG2) cells associated with G2/M phase cell cycle arrest, and reduced cyclin-dependent kinase (CDK) 4 and cyclin B1/D1 levels.
M21857 Atomoxetine Atomoxetine is a selective norepinephrine (NE) transporter inhibitor with a Ki of 5 nM that can be used in studies related to ADHD.
M20454 Duloxetine Duloxetine(LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake.
M20451 Granisetron Granisetron is a serotonin receptor (5HT-3 selective) antagonist that is used as an antiemetic and antinauseant for cancer chemotherapy.
M19194 Myristicin Myristicine is the main component of nutmeg essential oil from Myristica fragrans Houtt. Myristicine acts as a serotonin receptor antagonist, a weak monamine oxidase (MAO) inhibitor.

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