| Cat.No. | Name | Information |
|---|---|---|
| M2048 | Sumatriptan succinate | Sumatriptan succinate (GR 43175) is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for the research of migraine headache. |
| M3417 | Clozapine | Clozapine is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis. |
| M2821 | Lorcaserin hydrochloride | Lorcaserin hydrochloride is a selective full agonist of human 5-HT2C receptor with Ki of 15 nM. |
| M5656 | Fluoxetine hydrochloride | Fluoxetine hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. |
| M14577 | Fluoxetine | Fluoxetine (LY-110140 free base) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research. |
| M3659 | Pimavanserin | Pimavanserin is a selective serotonin 5-HT2A inverse agonist, with pIC50 and pKd of 8.73 and 9.3, respectively. |
| M3006 | Sertraline hydrochloride | Sertraline hydrochloride is a 5-HT antagonist with Ki of 13 nM. |
| M13870 | Lurasidone | Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. |
| M13869 | Ketanserin tartrate | Ketanserin (R41468) tartrate is a selective 5-HT2 receptor antagonist. Ketanserin tartrate also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM). |
| M13867 | Bromperidol | Bromperidol is a butyrophenone derivative, is a potent and long-acting neuroleptic, used as an antipsychotic in the treatment of schizophrenia. |
| M13866 | Alprenolol hydrochloride | Alprenolol (hydrochloride) is a non-selective beta blocker as well as 5-HT1A receptor antagonist. The reference for administration is 10 mg/kg. |
| M13865 | Alprenolol | Alprenolol is a non-selective beta blocker as well as 5-HT1A receptor antagonist. The reference for administration is 10 mg/kg. |
| M13360 | Serotonin | Serotonin is a monoamine neurotransmitter and endogenous 5-HT receptor agonist in CNS. Serotonin is also an inhibitor of catechin-o-methyltransferase (COMT) with a Ki value of 44 μM. Serotonin is also a natural product of animals. |
| M10608 | NLX-101 (F-15599) | NLX-101 (F-15599) is a highly selective G-protein biased 5-HT1A receptor agonist, with Ki of 3.4 nM. NLX-101 (F-15599) mediates antidepressant-like activity in rats via prefrontal cortex 5-HT 1A receptors. NLX-101 (F-15599) has over 1000-fold higher affinity for this target over other receptors. |
| M10160 | Lasmiditan | Lasmiditan (COL-144; LY573144) is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist, showed a K(i) value of 2.21 nM at the 5-HT(1F) receptor in vitro binding studies. |
| M10054 | Paroxetine | Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. |
| M9763 | AVN-492 | AVN-492 is a potent and selective 5-HT6R antagonist, binds to 5-HT6R (Ki = 91 pM). |
| M9584 | SAM-315 | SAM-31 (WAY-255315) is selective 5-Hydroxytryptamine-6 antagonists. |
| M9565 | RU 24969 hemisuccinate | RU 24969 hemisuccinate is a selective agonist at the 5-HT1A and 5-HT1B receptors. |
| M9308 | LY344864 | LY344864 is a selective 5-HT1F receptor agonist with an affinity of 6 nM (Ki). |
| M9252 | YL-0919 | YL-0919 is a novel 5-HT1A receptor agonist and selective serotonin reuptake inhibitor. YL-0919 inhibits the uptake of 5-HT into rat cerebral cortical synaptosomes and human recombinant cells with IC50 values of 1.78±0.34 nM and 1.93±0.18 nM, respectively. |
| M9025 | Idalopirdine hydrochloride | Idalopirdine hydrochloride is a potent and selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. |
| M9011 | PRX-08066 | PRX-08066 is a a novel 5-hydroxytryptamine receptor 2B antagonist with IC50 of 3.4 nM. |
| M8955 | MIN-101 | MIN-101 (Roluperidone) is a novel compound with affinities for 5-HT2A and sigma-2 receptors with Ki values of 7.53 nM and 8.19 nM, respectively. |
| M8942 | GSK163090 | GSK163090 is a potent, selective, and orally active 5-HT1A/B/D receptor antagonist. |
| M8932 | Eptapirone | Eptapirone (F11440) is a potent 5HT(1A) receptor agonist with marked anxiolytic and antidepressant potential. |
| M8900 | TG6-10-1 | TG6-10-1 is a potent and selective antagonist for the prostaglandin E2 receptor subtype EP2. |
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